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PMID: 7642312 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tumor necrosis factor alpha acts as an autocrine second signal with gamma interferon to induce nitric oxide in group B streptococcus-treated macrophages.

Infection and immunity ·Vol. 63 ·No. 9 ·1995-09-00 ·Pages 3715-7

Goodrum KJ, Dierksheide J, Yoder BJ

Abstract

Nitric oxide production by mouse macrophages treated with group B streptococci and gamma interferon was inhibited by cytochalasin B or by antibody neutralization of macrophage-derived tumor necrosis factor alpha. Phagocytosis-induced tumor necrosis factor alpha is responsible for group B streptococcus-induced nitric oxide production in interferon-treated macrophages.

MeSH Terms

Animals Cells, Cultured Cytochalasin B/pharmacology Interferon-gamma/pharmacology Macrophages/metabolism Mice Mice, Inbred BALB C Nitric Oxide/physiology Phagocytosis Recombinant Proteins Streptococcus agalactiae/physiology Tumor Necrosis Factor-alpha/physiology

Chemicals

Recombinant Proteins Tumor Necrosis Factor-alpha Nitric Oxide Cytochalasin B Interferon-gamma

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Goodrum K J

Department of Biological Sciences, Ohio University, Athens 45701-2979, USA.

Dierksheide J

Yoder B J

References (14)

14 references, click to expand

Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages.
Eur J Immunol. 1988 Oct;18(10):1587-92 PMID: 3142779
Role of complement receptors in opsonophagocytosis of group B streptococci by adult and neonatal neutrophils.
J Infect Dis. 1990 Aug;162(2):489-95 PMID: 2197341
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.
J Exp Med. 1991 Apr 1;173(4):869-79 PMID: 1672545
Phagocytosis enhances murine macrophage activation by interferon-gamma and tumor necrosis factor-alpha.
Eur J Immunol. 1991 Oct;21(10):2553-8 PMID: 1915557
IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha.
J Immunol. 1992 Jan 15;148(2):568-74 PMID: 1729374
Opsonin-independent phagocytosis of group B streptococci: role of complement receptor type three.
Infect Immun. 1992 Mar;60(3):1114-21 PMID: 1541527
Group B streptococcus-induced nitric oxide production in murine macrophages is CR3 (CD11b/CD18) dependent.
Infect Immun. 1994 Aug;62(8):3102-7 PMID: 8039877
Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection.
Infect Immun. 1993 Jan;61(1):227-35 PMID: 8418044
Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes.
J Immunol. 1993 Feb 1;150(3):888-95 PMID: 7678626
Production of tumor necrosis factor by human cells in vitro and in vivo, induced by group B streptococci.
J Pediatr. 1993 Aug;123(2):292-300 PMID: 8345430
Plasma nitric oxide levels in newborn infants with sepsis.
J Pediatr. 1993 Sep;123(3):435-8 PMID: 8355123
Role of glucose in interleukin-1 beta production by lipopolysaccharide-activated human monocytes.
J Cell Physiol. 1993 Oct;157(1):201-8 PMID: 8408238
The role of natural killer cells in innate resistance to infection.
Curr Opin Immunol. 1993 Aug;5(4):503-10 PMID: 8216925
Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.
Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8676-80 PMID: 1528880

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.63.9.3715-3717.1995

Published

1995-09-00

Pages

3715-7

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC173516

Subset

External Links

PubMed source DOI: 10.1128/iai.63.9.3715-3717.1995 PMC Full Text View journal details

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Tumor necrosis factor alpha acts as an autocrine second signal with gamma interferon to induce nitric oxide in group B streptococcus-treated macrophages.

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