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PMID: 7639742 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Ubiquitination of the rat uterine estrogen receptor: dependence on estradiol.

Biochemical and biophysical research communications ·Vol. 213 ·No. 1 ·1995-08-04 ·Pages 24-31

Nirmala PB, Thampan RV

Abstract

Using polyclonal antibodies against estrogen receptor and ubiquitin, the ubiquitination of the estrogen receptor has been demonstrated in both in vitro and in vivo conditions. The ubiquitination of the estrogen receptor is estradiol specific and is enhanced by estradiol. Estrogen withdrawal is associated with decreased ubiquitination of the estrogen receptor.

MeSH Terms

Animals Antibodies Cytosol/metabolism Electrophoresis, Polyacrylamide Gel Estradiol/pharmacology Female Immunoblotting Muscle, Smooth/drug effects,metabolism Ovariectomy Rats Rats, Wistar Receptors, Estrogen/drug effects,isolation & purification,metabolism Ubiquitins/metabolism Uterus/drug effects,metabolism

Chemicals

Antibodies Receptors, Estrogen Ubiquitins Estradiol

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Nirmala P B

Department of Biochemistry, School of Life Sciences, University of Hyderabad, India.

Thampan R V

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1006/bbrc.1995.2093

Published

1995-08-04

Pages

24-31

Language

English

Region

United States

NLM ID

0372516

Subset

External Links

PubMed source DOI: 10.1006/bbrc.1995.2093 View journal details

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Ubiquitination of the rat uterine estrogen receptor: dependence on estradiol.

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