Genetic approaches to nuclear pore structure and function.

Trends in genetics : TIG ·Vol. 11 ·No. 6 ·1995-06-00 ·Pages 235-41

Doye V, Hurt EC

Abstract

The major features of nucleocytoplasmic transport through nuclear pore complexes are conserved from yeast to humans. This transport machinery, which includes the 125 MDa nuclear pore complex structure, has been molecularly dissected in the yeast Saccharomyces cerevisiae by genetic approaches. Here, we summarize the genetic analyses used to elucidate structure-function relationships within this large supramolecular assembly.

Related Genes

MeSH Terms

Antibodies, Monoclonal/immunology Biological Transport Cell Nucleus/metabolism Cytoplasm/metabolism Eukaryotic Cells/metabolism Fungal Proteins/genetics,physiology Genes, Fungal Genes, Lethal Humans Macromolecular Substances Membrane Proteins/genetics,physiology Nuclear Envelope/genetics,physiology,ultrastructure Nuclear Proteins/genetics,physiology Saccharomyces cerevisiae/genetics,metabolism,ultrastructure Structure-Activity Relationship

Chemicals

Antibodies, Monoclonal Fungal Proteins Macromolecular Substances Membrane Proteins Nuclear Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Doye V

EMBL, Heidelberg, Germany.

Hurt E C

Article Info

Journal

Trends in genetics : TIG

Abbr.

Trends Genet

ISSN

0168-9525

DOI

10.1016/s0168-9525(00)89057-5

Published

1995-06-00

Pages

235-41

Language

English

Region

England

NLM ID

8507085

Subset

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1016/s0168-9525(00)89057-5 View journal details

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