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PMID: 7622249 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Regulation of production of tumor necrosis factor alpha in monocytes stimulated by the 30-kilodalton antigen of Mycobacterium tuberculosis.

Infection and immunity ·Vol. 63 ·No. 8 ·1995-08-00 ·Pages 3206-8

Averill L, Toossi Z, Aung H, Boom WH, Ellner JJ

Abstract

The 30-kDa secreted antigen of Mycobacterium tuberculosis was a strong inducer of tumor necrosis factor alpha in human monocytes. Our findings suggest that tumor necrosis factor alpha production may be up-regulated at both the posttranscriptional and transcriptional levels. Regulation at the posttranscriptional level probably reflects enhanced translational efficiency.

MeSH Terms

Antigens, Bacterial/chemistry,immunology Humans In Vitro Techniques Molecular Weight Monocytes/immunology Mycobacterium tuberculosis/immunology RNA, Messenger/metabolism Tumor Necrosis Factor-alpha/biosynthesis,genetics

Chemicals

Antigens, Bacterial RNA, Messenger Tumor Necrosis Factor-alpha

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Averill L

Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4984, USA.

Toossi Z

Aung H

Boom W H

Ellner J J

References (13)

13 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.63.8.3206-3208.1995

Published

1995-08-00

Pages

3206-8

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC173438

Subset

Grants

PHS HHS · A127243 · United States

NIAID NIH HHS · AI-18471 · United States

NIAID NIH HHS · AI-24298 · United States

External Links

PubMed source DOI: 10.1128/iai.63.8.3206-3208.1995 PMC Full Text View journal details

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Regulation of production of tumor necrosis factor alpha in monocytes stimulated by the 30-kilodalton antigen of Mycobacterium tuberculosis.

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