Delayed progression of diabetic retinopathy by divided insulin administration: a further follow-up.

Diabetologia ·Vol. 16 ·No. 1 ·1979-01-00 ·Pages 13-5

Eschwege E, Job D, Guyot-Argenton C, Aubry JP, Tchobroutsky G

Abstract

We have previously reported a slower rate of progression in the number of microaneurysms in insulin dependent diabetic patients treated by divided insulin injections when compared to patients receiving a single daily insulin injection [Diabetes 25, 463--469 (1976)]. This observation is strengthened by the present analysis which uses complementary data obtained after a further year follow up: the mean yearly increase in the number of microaneurysms was 9 +/- 1 in the single injection group and 3 +/- 1 in the multiple one (p less than 0.001).

MeSH Terms

Aneurysm/drug therapy,etiology Blood Glucose/analysis Blood Pressure Diabetic Retinopathy/drug therapy,physiopathology Drug Administration Schedule Follow-Up Studies Glycosuria Humans Insulin/administration & dosage,therapeutic use

Chemicals

Blood Glucose Insulin

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Eschwege E

Job D

Guyot-Argenton C

Aubry J P

Tchobroutsky G

References (14)

14 references, click to expand

Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus.
J Clin Endocrinol Metab. 1977 May;44(5):859-64 PMID: 858776
Studies of the rate of regression of the glomerular lesions in diabetic rats treated with pancreatic islet transplantation.
Diabetes. 1975 Mar;24(3):280-5 PMID: 123209
Control of blood glucose and diabetic vascular disease.
N Engl J Med. 1977 May 5;296(18):1060-3 PMID: 846550
Diabetic retinopathy, duration of diabetes and risk factors of atherosclerotic cardiovascular disease.
Acta Diabetol Lat. 1975 Jan-Feb;12(1):1-8 PMID: 1229803
Pancreatic islet transplantation. Effects on the glomerular lesions of experimental diabetes in the rat.
Diabetes. 1974 Sep;23(9):748-53 PMID: 4278212
On the pathogenesis of glomerular lesions in the alloxan diabetic rat. A light microscopic, immunofluorescent and ultrastructural study, including the effects of insulin treatment and immunosuppression.
Acta Med Scand Suppl. 1974;558:1-31 PMID: 4602045
Onset and progression of diabetic glomerulosclerosis; a prospective study based on serial renal biopsies.
Diabetes. 1975 Jan;24(1):1-9 PMID: 1120540
Effect of multiple daily insulin injections on the course of diabetic retinopathy.
Diabetes. 1976 May;25(5):463-9 PMID: 1269844
Glycosylated haemoglobin concentrations and clinitest results in insulin-dependent diabetes.
Lancet. 1977 Dec 3;2(8049):1156-7 PMID: 73063
Editorial: "Control" and diabetes.
N Engl J Med. 1976 Apr 29;294(18):1004-5 PMID: 1256496
Tobacco and other factors in the etiology of ischemic heart disease in man: results of a retrospective survey.
J Chronic Dis. 1966 Jan;19(1):35-55 PMID: 5903853
Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus.
N Engl J Med. 1976 Aug 19;295(8):417-20 PMID: 934240
Control of diabetes: an attempt to formulate policy guidelines in a department of medicine.
Diabetologia. 1974 Jun;10(3):201-4 PMID: 4602676
Relationship of microvascular disease in diabetes to metabolic control.
Diabetes. 1977 Aug;26(8):760-9 PMID: 885298

Article Info

Journal

Diabetologia

Abbr.

Diabetologia

ISSN

0012-186X

DOI

10.1007/BF00423144

Published

1979-01-00

Pages

13-5

Language

English

Region

Germany

NLM ID

0006777

Subset

External Links

PubMed source DOI: 10.1007/BF00423144 View journal details

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Delayed progression of diabetic retinopathy by divided insulin administration: a further follow-up.

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