Transmembrane signaling by antigen receptors of B and T lymphocytes.

The specificity of immune responses depends upon the activation of only those lymphocytes that recognize the introduced antigen. In recent years, a great deal has been learned about the structure of lymphocyte receptors for antigens and about their signal transduction mechanism. These receptors activate intracellular protein tyrosine kinases of at least two families, the Src family and the Syk/ZAP-70 family. Recent studies have given us considerable insight into the interactions of these two types of kinases and how they mediate antigen receptor signaling.