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PMID: 7595230 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

The Journal of experimental medicine ·Vol. 182 ·No. 5 ·1995-11-01 ·Pages 1591-6

Constant S, Pfeiffer C, Woodard A, Pasqualini T, Bottomly K

Abstract

Naive CD4+ T cells can differentiate into cells predominantly involved in humoral immunity, known as T helper type 2 cells (Th2), or cells involved in cell-mediated immunity, known as Th1 cells. In this report, we show that priming of CD4+ T cells bearing a transgene-encoded T cell receptor can lead to differentiation into Th1-like cells producing abundant interferon gamma when the cells are exposed to high antigen doses, while low doses of the same peptide induce cells with the same T cell receptor to differentiate into Th2-like cells producing abundant interleukin 4. Thus antigen dose is one factor that can control the differentiation fate of a naive CD4+ T cell.

MeSH Terms
Animals Antigens/immunology CD4-Positive T-Lymphocytes/cytology,immunology Cell Differentiation Cytochrome c Group/immunology Dose-Response Relationship, Immunologic Female Interferon-gamma/biosynthesis Interleukin-4/biosynthesis Male Mice Mice, Transgenic Moths Peptide Fragments/chemical synthesis,immunology Receptors, Antigen, T-Cell/chemistry,immunology Th1 Cells/cytology,immunology Th2 Cells/cytology,immunology
Chemicals
Antigens Cytochrome c Group Peptide Fragments Receptors, Antigen, T-Cell Interleukin-4 Interferon-gamma
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Constant S
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Pfeiffer C
Woodard A
Pasqualini T
Bottomly K
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.182.5.1591
Published
1995-11-01
Pages
1591-6
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2192213
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.182.5.1591 PMC Full Text View journal details
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