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PMID: 7560076 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach.

The Journal of clinical investigation ·Vol. 96 ·No. 4 ·1995-10-00 ·Pages 1845-58

Purcell-Huynh DA, Weinreb A, Castellani LW, Mehrabian M, Doolittle MH, Lusis AJ

Abstract

A genetic cross was constructed from two parental inbred strains of mice, NZB/BINJ and SM/J, which differ markedly in their plasma lipoprotein levels. Plasma lipid and apolipoprotein values were measured in 184 F2 progeny on a normal chow diet and on an atherogenic diet. Genetic markers were typed at 126 loci spanning all chromosomes except the Y. Statistical analysis revealed significant linkage or suggestive linkage of lipoprotein levels with markers on a number of chromosomes. Chromosome 1 markers were linked to levels of total cholesterol (lod 5.9) and high density lipoprotein (HDL) cholesterol (lod 8.1), chromosome 5 markers were linked to levels of total cholesterol (lod 6.7) and HDL cholesterol (lod 5.6), and chromosome 7 markers were linked to levels of total plasma triglycerides (lod 5.1) and free fatty acids (lod 5.6). Plasma apoAII levels were linked to the apoAII gene (lod score 19.6) and were highly correlated with plasma HDL cholesterol levels (r = 0.63, P = 0.0001), indicating that apoAII expression influences HDL cholesterol levels. Molecular studies suggested that structural differences in the apoAII polypeptide of the two strains may contribute to differences in clearance of the protein.

MeSH Terms
Amino Acid Sequence Animals Apolipoprotein A-II/genetics Apolipoproteins/metabolism Base Sequence Chromosome Mapping Crosses, Genetic Female Gene Expression Regulation Genetic Linkage Lipoproteins/metabolism Male Mice Mice, Inbred NZB Molecular Sequence Data Rabbits
Chemicals
Apolipoprotein A-II Apolipoproteins Lipoproteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Purcell-Huynh D A
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024, USA.
Weinreb A
Castellani L W
Mehrabian M
Doolittle M H
Lusis A J
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI118230
Published
1995-10-00
Pages
1845-58
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC185821
Subset
IM
Grants
NIGMS NIH HHS · GM08243 · United States
NHLBI NIH HHS · HL-28481 · United States
NHLBI NIH HHS · HL-42488 · United States
Databases
GENBANK
S79794
External Links
PubMed source DOI: 10.1172/JCI118230 PMC Full Text View journal details
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