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PMID: 75547 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Periodic loss of reactivity of a myeloma tumor with cytotoxic thymus-derived lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 1 ·1978-01-00 ·Pages 441-5

Russell JH, Hale AH, Ginns LC, Eisen HN

Abstract

During each transplantation passage of a line of mouse myeloma tumor MOPC-315 through syngeneic (BALB/c) hosts, the tumor cells lose reactivity with cytotoxic thymus-derived lymphocytes directed against products of the BALB/c major histocompatibility complex (H-2d) and regain reactivity on transfer to fresh hosts. In contrast to this cyclical change, the tumor cells remain uniformly reactive with anti-H-2d alloantisera throughout the transplantation cycle.

MeSH Terms
Animals Antigen-Antibody Reactions Cytotoxicity, Immunologic Epitopes Female H-2 Antigens Isoantibodies Male Mice Multiple Myeloma/immunology Neoplasm Transplantation Neoplasms, Experimental/immunology T-Lymphocytes/immunology Time Factors
Chemicals
Epitopes H-2 Antigens Isoantibodies
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Russell J H
Hale A H
Ginns L C
Eisen H N
References (17)
17 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.1.441
Published
1978-01-00
Pages
441-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC411265
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.1.441 PMC Full Text View journal details
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