Home LiteratureArticle Details

PMID: 7548847 Published · ppublish English Comparative Study Journal Article Review

Control of signal transduction and morphogenesis by Ras.

Seminars in cell biology ·Vol. 6 ·No. 2 ·1995-04-00 ·Pages 89-94

Hughes DA

Abstract

The single Ras homologue (Ras1) of S. pombe regulates two distinct processes: (1) Signal transduction through a MAP kinase-like protein kinase cascade in response to mating pheromones. In this pathway Ras1 interacts with the protein kinase Byr2 and leads to its activation in conjunction with a signal from the receptor-coupled, heterotrimeric G protein. (2) Polarized cell growth both during the cell cycle and during directed cell extension towards a mating partner. Ras1 interacts with Ral1/Scd1, a putative guanine-nucleotide-exchange factor, which could activate Cdc42, Rho-like GTP-binding protein. Cdc42 may regulate the dynamics of the actin cytoskeleton.

Related Genes

gap1 ral1 ral2 ral3 ral4 ras1 sar1 scd1 scd2 st36

MeSH Terms

Amino Acid Sequence DNA-Binding Proteins Eukaryotic Cells/physiology Fungal Proteins/physiology GTP-Binding Proteins/physiology Genes, Fungal Genes, ras Guanosine Triphosphate/physiology Intercellular Signaling Peptides and Proteins Molecular Sequence Data Morphogenesis/physiology Peptides/physiology Pheromones/physiology Phosphorylation Protein Kinases/physiology Protein Processing, Post-Translational Saccharomyces cerevisiae/physiology Saccharomyces cerevisiae Proteins Schizosaccharomyces/genetics,physiology,ultrastructure Schizosaccharomyces pombe Proteins Signal Transduction/physiology Species Specificity ras Proteins

Chemicals

DNA-Binding Proteins Fungal Proteins Intercellular Signaling Peptides and Proteins Mating Factor, S pombe Peptides Pheromones Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins mfm1 protein, S pombe Guanosine Triphosphate Protein Kinases GTP-Binding Proteins RAS1 protein, S cerevisiae Ras1 protein, S pombe ras Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hughes D A

CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London, UK.

Article Info

Journal

Seminars in cell biology

Abbr.

Semin Cell Biol

ISSN

1043-4682

DOI

10.1016/1043-4682(95)90005-5

Published

1995-04-00

Pages

89-94

Language

English

Region

England

NLM ID

9007587

Subset

External Links

PubMed source DOI: 10.1016/1043-4682(95)90005-5

Analysis Services

Control of signal transduction and morphogenesis by Ras.

Contact

WeChat Official Account