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PMID: 7546382 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms.

Current opinion in immunology ·Vol. 7 ·No. 2 ·1995-04-00 ·Pages 228-34

Strasser A

Abstract

During their development and after their functional activation most lymphocytes die, either because they fail to receive a survival signal or because they are actively killed. Recent experiments on Bcl-2 and Fas/Apo-1 have provided evidence that these two death processes are subject to distinct genetic control.

MeSH Terms
Animals Apoptosis/immunology Cell Survival/immunology Humans Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-bcl-2 fas Receptor/genetics
Chemicals
Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 fas Receptor
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Strasser A
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
DOI
10.1016/0952-7915(95)80007-7
Published
1995-04-00
Pages
228-34
Language
English
Region
England
NLM ID
8900118
Subset
IM
Grants
NCI NIH HHS · CA43540 · United States
External Links
PubMed source DOI: 10.1016/0952-7915(95)80007-7 View journal details
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