The role of IL-12 in the induction of organ-specific autoimmune diseases.

Immunology today ·Vol. 16 ·No. 8 ·1995-08-00 ·Pages 383-6

Trembleau S, Germann T, Gately MK, Adorini L

Abstract

The concept that T cells are subdivided into T helper 1 (Th1) and Th2 subsets was recently extended to suggest that Th1 cells contribute to the pathogenesis of several organ-specific autoimmune diseases, whereas Th2 cells inhibit disease development. Here, Sylvie Trembleau and colleagues examine the role of interleukin 12 (IL-12), a key cytokine guiding the development of Th1 cells, in the induction of autoimmune diseases, and discuss potential immunointervention strategies based on administration of IL-12 antagonists.

MeSH Terms

Animals Antibodies, Monoclonal/immunology,pharmacology,therapeutic use Arthritis/chemically induced,immunology Autoimmune Diseases/chemically induced,drug therapy,immunology Collagen/toxicity Diabetes Mellitus, Type 1/chemically induced,immunology Drug Design Encephalomyelitis, Autoimmune, Experimental/immunology,therapy Female Immunosuppressive Agents/pharmacology,therapeutic use Immunotherapy, Adoptive Interleukin-12/antagonists & inhibitors,physiology,toxicity Mice Mice, Inbred BALB C Mice, Inbred NOD Models, Immunological Organ Specificity/immunology Th1 Cells/immunology

Chemicals

Antibodies, Monoclonal Immunosuppressive Agents Interleukin-12 Collagen

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Trembleau S

Roche Milano Ricerche, Italy.

Germann T

Gately M K

Adorini L

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(95)80006-9

Published

1995-08-00

Pages

383-6

Language

English

Region

England

NLM ID

8008346

Subset

External Links

PubMed source DOI: 10.1016/0167-5699(95)80006-9

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The role of IL-12 in the induction of organ-specific autoimmune diseases.

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