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Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.
J Biol Chem. 1992 Dec 15;267(35):24921-4
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Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin.
J Biol Chem. 1991 Aug 15;266(23):14831-4
PMID: 1714444
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Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma.
J Clin Invest. 1991 Jun;87(6):1883-8
PMID: 2040684
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Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):5026-30
PMID: 1711216
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Differential expression of thrombospondin 1, 2, and 3 during murine development.
Dev Dyn. 1993 May;197(1):40-56
PMID: 8400410
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Angiogenesis in cancer, vascular, rheumatoid and other disease.
Nat Med. 1995 Jan;1(1):27-31
PMID: 7584949
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Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.
Science. 1994 Sep 9;265(5178):1582-4
PMID: 7521539
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Extracellular matrix: the thrombospondin family.
Curr Biol. 1993 Mar;3(3):188-90
PMID: 15335796
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Thrombospondins: structure and regulation of expression.
FASEB J. 1992 Nov;6(14):3290-9
PMID: 1426766
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Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis.
Am J Pathol. 1994 Apr;144(4):820-8
PMID: 7512793
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Mice develop normally without tenascin.
Genes Dev. 1992 Oct;6(10):1821-31
PMID: 1383086
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High level thrombospondin 1 expression in two NIH 3T3 cloned lines confers serum- and anchorage-independent growth.
J Biol Chem. 1993 Feb 5;268(4):2899-903
PMID: 8428963
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Thrombospondin 1 as an enzyme inhibitor.
Thromb Haemost. 1994 Dec;72(6):787-92
PMID: 7740442
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Distinct effects of thrombospondin-1 and CISP/thrombospondin-2 on adrenocortical cell spreading.
Mol Cell Endocrinol. 1994 Dec;106(1-2):181-6
PMID: 7895906
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A novel protein interacts with the major transforming growth factor-beta responsive element in the plasminogen activator inhibitor type-1 gene.
J Biol Chem. 1994 Aug 26;269(34):21500-4
PMID: 8063785
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Disulfides modulate RGD-inhibitable cell adhesive activity of thrombospondin.
J Cell Biol. 1992 Aug;118(3):693-701
PMID: 1379247
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Modulation of thrombospondin gene expression during osteoblast differentiation in MC3T3-E1 cells.
Bone. 1992;13(2):197-201
PMID: 1576018
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Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins.
J Cell Biol. 1993 Mar;120(5):1079-81
PMID: 7679670
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Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type I repeats of thrombospondin.
J Cell Biochem. 1993 Sep;53(1):74-84
PMID: 8227183
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Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity.
J Cell Biol. 1993 Jul;122(2):497-511
PMID: 7686555
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Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.
J Biol Chem. 1994 Oct 28;269(43):26775-82
PMID: 7929413
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A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.
Proc Natl Acad Sci U S A. 1990 Sep;87(17):6624-8
PMID: 1697685
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Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis.
Cancer Res. 1994 Dec 15;54(24):6504-11
PMID: 7527299
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Matrix-bound thrombospondin promotes angiogenesis in vitro.
J Cell Biol. 1994 Jan;124(1-2):183-93
PMID: 7507491
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Thrombospondins.
Methods Enzymol. 1994;245:62-85
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Modulation of thrombospondin expression during differentiation of embryonal carcinoma cells.
J Cell Physiol. 1994 Mar;158(3):495-505
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Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor.
J Biol Chem. 1987 Jun 25;262(18):8821-5
PMID: 3597395
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Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines.
Int J Cancer. 1994 Oct 15;59(2):191-5
PMID: 7927918
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Colocalization of thrombospondin and syndecan during murine development.
Dev Dyn. 1992 Apr;193(4):346-58
PMID: 1380845
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Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development.
J Biol Chem. 1992 Feb 15;267(5):3274-81
PMID: 1371115
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Role of thrombospondin in mesangial cell growth: possible existence of an autocrine feedback growth circuit.
Kidney Int. 1994 Aug;46(2):350-7
PMID: 7967346