The effect of colchicine and vinblastine on bleomycin-induced lung fibrosis in rats.

Acta physiologica Hungarica ·Vol. 82 ·No. 4 ·1994-00-00 ·Pages 383-9

Ledwozyw A

Abstract

The effect of colchicine and vinblastine on collagenase, lysyl oxidase and prolyl hydroxylase activities as well as on collagen cross-linking and types of this protein in bleomycin induced lung fibrosis in rats was investigated. Both colchicine and vinblastine diminish bleomycin-induced changes in the above-mentioned enzyme activities as well as collagen cross-linking and normalize type I/type III collagen ratio.

MeSH Terms

Animals Bleomycin Colchicine/pharmacology Collagen/drug effects Collagenases/metabolism Cross-Linking Reagents/pharmacology Procollagen-Proline Dioxygenase/metabolism Protein-Lysine 6-Oxidase/metabolism Pulmonary Fibrosis/chemically induced,drug therapy Rats Rats, Wistar Vinblastine/pharmacology

Chemicals

Cross-Linking Reagents Bleomycin Vinblastine Collagen Procollagen-Proline Dioxygenase Protein-Lysine 6-Oxidase Collagenases Colchicine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ledwozyw A

Department of Pathophysiology, Veterinary Faculty of Agricultural Academy, Lublin, Poland.

Article Info

Journal

Acta physiologica Hungarica

Abbr.

Acta Physiol Hung

ISSN

0231-424X

Published

1994-00-00

Pages

383-9

Language

English

Region

Hungary

NLM ID

8309201

Subset

External Links

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The effect of colchicine and vinblastine on bleomycin-induced lung fibrosis in rats.

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