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题目:: Generation of memory B cells and plasma cells in vitro.
作者:: Arpin(C),Déchanet(J),Van Kooten(C),Merville(P),Grouard(G),Brière(F),Banchereau(J),Liu(Y J)
状态:: 发布时间1995-05-30 , 更新时间 2007-03-19
期刊:: Science
摘要:: After germinal center B cells undergo somatic mutation and antigen selection, they become either memory B cells or plasma cells, but the signal requirements that control entry into either pathway have been unclear. When purified human germinal center cells were cultured with interleukin-2, interleukin-10, and cells expressing CD40 ligand, cells with characteristics of memory B cells were generated. Removal of CD40 ligand from the system resulted in terminal differentiation of germinal center B cells into cells with the characteristics of plasma cells. These results indicate that CD40 ligand directs the differentiation of germinal center B cells toward memory B cells rather than toward plasma cells.
语言:: eng
DOI:

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