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PMID: 7535114 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Extended dipolar chain model for ion channels: electrostriction effects and the translocational energy barrier.

Biophysical journal ·Vol. 68 ·No. 2 ·1995-02-00 ·Pages 427-33

Sancho M, Partenskii MB, Dorman V, Jordan PC

Abstract

We reinvestigate the dipolar chain model for an ion channel. Our goal is to account for the influence that ion-induced electrostriction of channel water has on the translocational energy barriers experienced by different ions in the channel. For this purpose, we refine our former model by relaxing the positional constraint on the ion and the water dipoles and by including Lennard-Jones contributions in addition to the electrostatic interactions. The positions of the ion and the waters are established by minimization of the free energy. As before, interaction with the external medium is described via the image forces. Application to alkali cations show that the short range interactions modulate the free energy profiles leading to a selectivity sequence for translocation. We study the influence of some structural parameters on this sequence and compare our theoretical predictions with observed results for gramicidin.

MeSH Terms
Electrochemistry Ion Channels/chemistry Ions Models, Chemical Thermodynamics Water/chemistry
Chemicals
Ion Channels Ions Water
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sancho M
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02254.
Partenskii M B
Dorman V
Jordan P C
References (19)
19 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(95)80204-3
Published
1995-02-00
Pages
427-33
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1281707
Subset
IM
Grants
NIGMS NIH HHS · GM-28643 · United States
External Links
PubMed source DOI: 10.1016/S0006-3495(95)80204-3 PMC Full Text View journal details
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