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PMID: 7533912 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Neurotransmitters and cytokines in CNS pathology.

Progress in brain research ·Vol. 103 ·1994-00-00 ·Pages 319-30

Mitrovic B, Martin FC, Charles AC, Ignarro LJ, Anton PA, Shanahan F, Merrill JE

Abstract

In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves cell contact to oligodendrocytes with activated, viable microglia (or inflammatory macrophages), surface TNF-alpha, surface adhesion molecules, and production of NO. Precise mechanisms of TNF-alpha and ICAM-1/LFA-1 participation and the nature of the susceptibility of the oligodendrocyte are currently being studied.

MeSH Terms

AIDS Dementia Complex/metabolism Animals Astrocytes/metabolism Calcium/physiology Cell Adhesion Molecules, Neuronal/physiology Cell Death Cells, Cultured Cytokines/biosynthesis,genetics Demyelinating Diseases Gene Expression Regulation Macrophages/metabolism Multiple Sclerosis/metabolism,pathology Neuroimmunomodulation Nitric Oxide/physiology,toxicity Oligodendroglia/pathology Rats Receptors, Neurokinin-1/physiology Substance P/physiology

Chemicals

Cell Adhesion Molecules, Neuronal Cytokines Receptors, Neurokinin-1 Nitric Oxide Substance P Calcium

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Mitrovic B

UCLA School of Medicine 90024.

Martin F C

Charles A C

Ignarro L J

Anton P A

Shanahan F

Merrill J E

Article Info

Journal

Progress in brain research

Abbr.

Prog Brain Res

ISSN

0079-6123

DOI

10.1016/s0079-6123(08)61146-2

Published

1994-00-00

Pages

319-30

Language

English

Region

Netherlands

NLM ID

0376441

Subset

Grants

NINDS NIH HHS · NS26983 · United States

NINDS NIH HHS · NS30768 · United States

External Links

PubMed source DOI: 10.1016/s0079-6123(08)61146-2 View journal details

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