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PMID: 7508419 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule, CD1d.

Immunology ·Vol. 80 ·No. 4 ·1993-12-00 ·Pages 561-5

Canchis PW, Bhan AK, Landau SB, Yang L, Balk SP, Blumberg RS

Abstract

The CD1 gene family is composed of five distinct molecules: CD1a, b, c, d and e. CD1a, b and c are primarily expressed thymically with limited extrathymic expression. Preliminary studies have shown that CD1d is primarily expressed extrathymically in gastrointestinal epithelial cells, renal tubular epithelial cells and B cells. This report characterizes the expression of CD1d in a variety of human tissues by immunohistochemistry using two anti-human CD1d monoclonal antibodies (mAb). CD1d was found in a wide range of tissues including the intestine, liver, pancreas, skin, kidney, uterus, conjunctiva, epididymis, thymus and tonsil. Within those tissues CD1d was mainly present in epithelial cells, vascular smooth muscle cells and parenchymal cells. Therefore, the tissue distribution of CD1d is distinct from CD1a-c and classical major histocompatibility complex (MHC) proteins implicating a unique role for CD1d in the immune system.

MeSH Terms
Antibodies, Monoclonal/immunology Antigens, CD/analysis Antigens, CD1 Epithelium/immunology Humans Immunoenzyme Techniques Intestines/immunology Kidney/immunology Liver/immunology Muscle, Smooth, Vascular/immunology Skin/immunology Tissue Distribution
Chemicals
Antibodies, Monoclonal Antigens, CD Antigens, CD1
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Canchis P W
Gastroenterology Division, Brigham and Women's Hospital, Boston, MA 02115.
Bhan A K
Landau S B
Yang L
Balk S P
Blumberg R S
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1993-12-00
Pages
561-5
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1422252
Subset
IM
Grants
NIDDK NIH HHS · 2P01-DK33506 · United States
NIDDK NIH HHS · DK44319-01 · United States
NIDDK NIH HHS · P30-DK4351 · United States
External Links
PubMed source PMC Full Text View journal details
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