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PMID: 7495566 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Aquaporin water channels: unanswered questions and unresolved controversies.

Current opinion in cell biology ·Vol. 7 ·No. 4 ·1995-08-00 ·Pages 472-83

Agre P, Brown D, Nielsen S

Abstract

The long-standing biophysical question of how water crosses plasma membranes has been answered by the recent discovery of the aquaporins. Identification of this large family of membrane water-transport proteins has generated new questions about the physiological functions, tissue distributions, and regulatory mechanisms of individual aquaporins. The fast pace of developments in this field has also resulted in major discrepancies in published reports which warrant resolution.

MeSH Terms
Animals Biophysical Phenomena Biophysics Body Water/metabolism Carrier Proteins/metabolism Cell Membrane Permeability/physiology Humans Ion Channels Membrane Proteins/metabolism Tissue Distribution
Chemicals
Carrier Proteins Ion Channels Membrane Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Agre P
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185, USA.
Brown D
Nielsen S
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/0955-0674(95)80003-4
Published
1995-08-00
Pages
472-83
Language
English
Region
England
NLM ID
8913428
PMCID
PMC7135066
Subset
IM
Grants
NIDDK NIH HHS · DK38452 · United States
NHLBI NIH HHS · HL33991 · United States
NHLBI NIH HHS · HL48268 · United States
External Links
PubMed source DOI: 10.1016/0955-0674(95)80003-4 PMC Full Text View journal details
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