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PMID: 7488167 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

The role of iron in beta amyloid toxicity.

Biochemical and biophysical research communications ·Vol. 216 ·No. 2 ·1995-11-13 ·Pages 702-7

Schubert D, Chevion M

Abstract

There is evidence that oxidative damage plays a causative role in Alzheimer's disease and amyloid beta protein (A beta) toxicity. Iron is frequently a potent facilitator of free radical production due to its ability to mediate the conversion of H2O2 to hydroxyl radicals via the Fenton reaction or by virtue of hypervalent iron compounds. It is shown here that iron facilitates A beta toxicity to cultured cells.

MeSH Terms

Alzheimer Disease/physiopathology Amyloid beta-Peptides/toxicity Animals Cell Death/drug effects Cell Survival/drug effects Cells, Cultured Cerebral Cortex/cytology,drug effects,pathology Clone Cells Deferoxamine/pharmacology Drug Synergism Humans Hydrogen Peroxide/pharmacology Iron/toxicity Iron Chelating Agents/pharmacology Neurons/cytology,drug effects,pathology Neurotoxins/toxicity Peptide Fragments/toxicity

Chemicals

Amyloid beta-Peptides Iron Chelating Agents Neurotoxins Peptide Fragments amyloid beta-protein (1-40) amyloid beta-protein (25-35) Hydrogen Peroxide Iron Deferoxamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schubert D

Salk Institute, La Jolla, California 92037, USA.

Chevion M

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1006/bbrc.1995.2678

Published

1995-11-13

Pages

702-7

Language

English

Region

United States

NLM ID

0372516

Subset

Grants

NINDS NIH HHS · P01 NS28121 · United States

NINDS NIH HHS · R01 NS09658 · United States

External Links

PubMed source DOI: 10.1006/bbrc.1995.2678 View journal details

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The role of iron in beta amyloid toxicity.

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