Origins of anti-DNA antibodies and their implications for B-cell tolerance.

Amino Acid Sequence Animals Antibodies, Antinuclear/chemistry,genetics,immunology Antibody Diversity Antibody Specificity Arginine/chemistry Autoantigens/chemistry,immunology Autoimmune Diseases/immunology B-Lymphocytes/immunology Base Sequence DNA/chemistry,immunology Deoxyribonucleoproteins/immunology Genes, Immunoglobulin Humans Immune Tolerance Immunoglobulin Heavy Chains/genetics Immunoglobulin Variable Region/genetics Lupus Erythematosus, Systemic/immunology Mice Models, Immunological Molecular Sequence Data Point Mutation Recombinant Fusion Proteins/immunology Sequence Alignment Sequence Homology, Amino Acid

Antibodies, Antinuclear Autoantigens Deoxyribonucleoproteins Immunoglobulin Heavy Chains Immunoglobulin Variable Region Recombinant Fusion Proteins DNA Arginine