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PMID: 7470085 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Spontaneous lysosomal enzyme secretion by a murine macrophage-like cell line.

The Biochemical journal ·Vol. 190 ·No. 3 ·1980-09-15 ·Pages 847-50

Jessup W, Dean RT

Abstract

Lysosomal enzyme secretion by the murine macrophage-like cell line, P388D1, was compared with that of normal peritoneal macrophages. Unlike macrophages, lysosomal hydrolase secretion by P388D1 cells occurred spontaneously in vitro and was not further stimulated by the presentation of inflammatory agents such as zymosan and asbestos.

MeSH Terms
Animals Ascitic Fluid/cytology Cell Line Hexosaminidases/metabolism Hydrolases/metabolism Lysosomes/drug effects,enzymology Macrophages/drug effects,enzymology Mice
Chemicals
Hydrolases Hexosaminidases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jessup W
Dean R T
References (10)
10 references, click to expand
  1. In vitro synthesis and secretion of lysozyme by mononuclear phagocytes.
    J Exp Med. 1974 May 1;139(5):1228-48 PMID: 4825244
  2. Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes.
    Nature. 1974 Oct 4;251(5474):423-5 PMID: 4424310
  3. Identification of macrophage-like characteristics in a cultured murine tumor line.
    J Immunol. 1975 Feb;114(2 pt 2):894-7 PMID: 1167564
  4. Direct toxic effects of immunopotentiators on monocytic, myelomonocytic, and histiocytic or macrophage tumor cells in culture.
    Cancer Res. 1977 Feb;37(2):546-50 PMID: 318922
  5. The selective release of lysosomal acid hydrolases from mouse peritoneal macrophages by stimuli of chronic inflammation.
    Br J Exp Pathol. 1977 Jun;58(3):315-26 PMID: 871380
  6. Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1.
    J Immunol. 1977 Dec;119(6):2060-6 PMID: 915291
  7. Cystic fibrosis: leakage of lysosomal enzymes and of alkaline phosphatase into the extracellular space.
    Biochem Biophys Res Commun. 1977 Dec 7;79(3):741-8 PMID: 597304
  8. Properties of a murine monocytic tumor cell line J-774 in vitro. II. Enzyme activities.
    Exp Cell Res. 1978 Aug;115(1):63-72 PMID: 354950
  9. Lysosomal enzyme secretion by macrophages during intracellular storage of particles.
    Biochim Biophys Acta. 1979 Apr 18;584(1):57-65 PMID: 444581
  10. Induction of macrophage lysosomal enzyme secretion by agents acting at the plasma membrane.
    Exp Cell Biol. 1979;47(6):454-62 PMID: 520650
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1900847
Published
1980-09-15
Pages
847-50
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1162168
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1900847 PMC Full Text View journal details
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