Home LiteratureArticle Details
PMID: 7470046 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Secretion granules of transplantable pancreatic acinar carcinoma of rat.

The Biochemical journal ·Vol. 188 ·No. 3 ·1980-06-15 ·Pages 921-4

Reddy JK, Reddy MK, Hansen LJ, Qureshi SA

Abstract

Secretion granules of the rat transplantable pancreatic acinar carcinoma and of normal rat pancreas were isolated by differential centrifugation. Analysis of the granule content by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis and isoelectric focusing procedures combined with specific enzyme assays indicated essential qualitative similarities between normal and neoplastic secretory proteins, suggesting retention of enzymic differentiation in this pancreatic acinar carcinoma. Accordingly, this epithelial tumor should serve as an important model for examination of regulatory mechanisms in cell differentiation and neoplasia.

MeSH Terms
Animals Carcinoma/enzymology,ultrastructure Cytoplasmic Granules/enzymology,ultrastructure Male Microscopy, Electron Neoplasms, Experimental/enzymology,ultrastructure Pancreas/enzymology,ultrastructure Pancreatic Neoplasms/enzymology,ultrastructure Rats Rats, Inbred F344
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Reddy J K
Reddy M K
Hansen L J
Qureshi S A
References (17)
17 references, click to expand
  1. Establishment and characterization of primary human pancreatic carcinoma in continuous cell culture and in nude mice.
    Br J Cancer. 1979 Feb;39(2):143-51 PMID: 435363
  2. Concanavalin A agglutinability and surface microvilli of dissociated normal and neoplastic pancreatic acinar cells of the rat.
    Exp Cell Res. 1979 Apr;120(1):55-61 PMID: 436953
  3. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  4. A stable starch substrate for the determination of amylase in serum and other body fluids.
    Am J Clin Pathol. 1959 Jul;32(1):97-9 PMID: 13661129
  5. On the protein composition of bovine pancreatic zymogen granules.
    J Biol Chem. 1963 Jun;238:2054-70 PMID: 13950163
  6. The relation of structure to enzymatic activity in ribonuclease.
    Ann N Y Acad Sci. 1959 Sep 4;81:542-69 PMID: 14404174
  7. Transplantable ductal adenocarcinoma of the Syrian hamster pancreas.
    Cancer Res. 1979 Feb;39(2 Pt 1):452-8 PMID: 216489
  8. A specific method for serum lipase determination.
    Clin Chim Acta. 1966 Mar;13(3):352-8 PMID: 5943826
  9. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
  10. Subcellular fractionation of the pancreas.
    Methods Enzymol. 1974;31:41-59 PMID: 4419641
  11. Studies on the guinea pig pancreas. Fractionation and partial characterization of exocrine proteins.
    J Biol Chem. 1974 Dec 10;249(23):7420-31 PMID: 4436317
  12. Studies on the guinea pig pancreas. Parallel discharge of exocrine enzyme activities.
    J Biol Chem. 1975 Apr 10;250(7):2660-70 PMID: 1123325
  13. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas.
    Int J Cancer. 1975 May 15;15(5):741-7 PMID: 1140870
  14. Intracellular aspects of the process of protein synthesis.
    Science. 1975 Aug 1;189(4200):347-58 PMID: 1096303
  15. Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase.
    Int J Cancer. 1977 Jan;19(1):128-35 PMID: 832918
  16. Transplantable pancreatic carcinoma of the rat.
    Science. 1977 Oct 7;198(4312):78-80 PMID: 897688
  17. The peroxisome proliferation-associated polypeptide in rat liver.
    Biochem Biophys Res Commun. 1977 Aug 8;77(3):824-9 PMID: 901515
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1880921
Published
1980-06-15
Pages
921-4
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1161978
Subset
IM
Grants
NCI NIH HHS · CA 23055 · United States
External Links
PubMed source DOI: 10.1042/bj1880921 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2