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PMID: 7453823 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

A model from electron microscopy for the molecular structure of fibrinogen and fibrin.

Nature ·Vol. 289 ·No. 5795 ·1981-01-22 ·Pages 263-7

Weisel JW, Phillips GN, Cohen C

Abstract

The overall architecture of the fibrinogen molecule and aspects of its packing to form fibrin have been derived from a study of electron microscope images of ordered arrays. The molecule, of length 450 A, is seen in more detail than the Hall-Slayter model and is made up of seven globular domains connected by rod-like segments.

MeSH Terms
Blood Coagulation Crystallography Fibrin Fibrinogen/physiology Microscopy, Electron/methods Models, Molecular Protein Conformation
Chemicals
Fibrin Fibrinogen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Weisel J W
Phillips G N
Cohen C
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/289263a0
Published
1981-01-22
Pages
263-7
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
PHS HHS · AN17346 · United States
External Links
PubMed source DOI: 10.1038/289263a0 View journal details
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