Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions.

British journal of experimental pathology ·Vol. 61 ·No. 5 ·1980-10-00 ·Pages 497-504

Robins PG

Abstract

It is shown by transmission electron-microscopy that the first structural change in rats, following a dose of aspirin, is to the basement membrane of the endothelial cell of the capillary and post-capillary venule. This leads to the breakdown of small blood vessels before any other cytolytic effect. This is a focal effect and it is proposed that the erosion develops as an ischaemic infarct.

MeSH Terms

Animals Aspirin/toxicity Capillaries/drug effects,ultrastructure Endothelium/drug effects,ultrastructure Female Gastric Mucosa/blood supply,drug effects,ultrastructure Microscopy, Electron Rats Stomach Diseases/chemically induced,pathology

Chemicals

Aspirin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Robins P G

References (17)

17 references, click to expand

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Article Info

Journal

British journal of experimental pathology

Abbr.

Br J Exp Pathol

ISSN

0007-1021

Published

1980-10-00

Pages

497-504

Language

English

Region

England

NLM ID

0372543

PMCID

PMC2041530

Subset

External Links

PubMed source PMC Full Text View journal details

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Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions.

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