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PMID: 7447932 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Quantitative importance of non-skeletal-muscle sources of N tau-methylhistidine in urine.

The Biochemical journal ·Vol. 190 ·No. 1 ·1980-07-15 ·Pages 225-8

Millward DJ, Bates PC, Grimble GK, Brown JG, Nathan M, Rennie MJ

Abstract

Direct measurement of N tau-methylhistidine turnover in skeletal muscle, skin and gastrointestinal muscle indicates that these three tissues contribute only 24.9, 6.8 and 9.8% of the total urinary excretion. Measurement of the decay rate of radioactively labelled N tau-methylhistidine in urine indicates that skeletal muscle accounts for 74.5% of the urinary excretion and this is probably an overestimate. These results suggest that the common assumption, that N tau-methylhistidine in urine originates almost entirely from skeletal muscle, may be wrong.

MeSH Terms

Animals Female Histidine/analogs & derivatives Kinetics Methylhistidines/metabolism,urine Muscle, Smooth/metabolism Muscles/metabolism Rats Skin/metabolism

Chemicals

Methylhistidines Histidine

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Millward D J

Bates P C

Grimble G K

Brown J G

Nathan M

Rennie M J

References (13)

13 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1900225

Published

1980-07-15

Pages

225-8

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1162081

Subset

External Links

PubMed source DOI: 10.1042/bj1900225 PMC Full Text View journal details

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Quantitative importance of non-skeletal-muscle sources of N tau-methylhistidine in urine.

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