Relationship between oestrogen-receptor content and histological grade in human primary breast tumours.

British journal of cancer ·Vol. 38 ·No. 6 ·1978-12-00 ·Pages 745-8

Maynard PV, Davies CJ, Blamey RW, Elston CW, Johnson J, Griffiths K

Abstract

A series of 300 patients presenting consecutively with primary operable breast cancer has been studied. A significant correlation was found between oestrogen-receptor (ER) content and histological grade: the better-differentiated tumours rarely lacked receptor. This correlation was significant only in women defined as post-menopausal. Data on early recurrence of disease indicate a worse prognosis for women in whom primary tumours are ER-.

MeSH Terms

Adult Aged Bone Neoplasms Breast Neoplasms/analysis,pathology Cell Transformation, Neoplastic Female Humans Lung Neoplasms Lymph Nodes/pathology Mastectomy Menopause Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local Prognosis Receptors, Estrogen/analysis

Chemicals

Receptors, Estrogen

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Maynard P V

Davies C J

Blamey R W

Elston C W

Johnson J

Griffiths K

References (12)

12 references, click to expand

Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.
Br J Cancer. 1957 Sep;11(3):359-77 PMID: 13499785
Survival in breast cancer cases in relation to the structure of the primary tumor and regional lymph nodes.
Surg Gynecol Obstet. 1955 May;100(5):543-51 PMID: 14373353
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer.
Cancer Res. 1977 Dec;37(12):4669-71 PMID: 922747
Histology in breast cancer prognosis.
Br J Cancer. 1972 Apr;26(2):129-38 PMID: 4114100
Tumor grade in the prognosis of breast cancer.
Nebr State Med J. 1970 Jul;55(7):405-9 PMID: 4247543
Mathematical theory of complex ligand-binding systems of equilibrium: some methods for parameter fitting.
Anal Biochem. 1972 Aug;48(2):317-38 PMID: 4627078
Pathological review of breast lesions analyzed for estrogen receptor protein.
Cancer Res. 1975 Nov;35(11 Pt 1):3187-94 PMID: 171066
Hormone receptors: studies on the interaction of estrogen with the uterus.
Recent Prog Horm Res. 1968;24:45-80 PMID: 4885833
A two-step mechanism for the interaction of estradiol with rat uterus.
Proc Natl Acad Sci U S A. 1968 Feb;59(2):632-8 PMID: 5238991
The binding of estradiol-17beta to human breast cancers and other tissues in vitro.
Cancer Res. 1970 Mar;30(3):692-8 PMID: 5463903
Histological grading in carcinoma of the breast.
Br J Cancer. 1966 Mar;20(1):36-40 PMID: 5937523

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1978.282

Published

1978-12-00

Pages

745-8

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2009828

Subset

External Links

PubMed source DOI: 10.1038/bjc.1978.282 PMC Full Text View journal details

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Relationship between oestrogen-receptor content and histological grade in human primary breast tumours.

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