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PMID: 7428691 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Induction of nuclear androgen-binding sites in epithelium of the embryonic urinary bladder by mesenchyme of the urogenital sinus of embryonic mice.

Endocrinology ·Vol. 107 ·No. 6 ·1980-12-00 ·Pages 1767-70

Cunha GR, Reese BA, Sekkingstad M

Abstract

Mesenchyme of the embryonic urogenital sinus induces epithelium of the embryonic urinary bladder to form prostatic acini. The induced glandular epithelium exhibits nuclear androgen-binding sites, as demonstrated autoradiographically. This suggests that the expression of androgen receptor activity in an epithelium is dependent upon the mesenchyme with which it is associated during development.

MeSH Terms

Animals Cell Nucleus/metabolism Dihydrotestosterone/metabolism Embryo, Mammalian/physiology Epithelium/metabolism Female Male Mice Mice, Inbred BALB C Pregnancy Prostate/embryology Receptors, Androgen/metabolism Receptors, Steroid/metabolism Transplantation, Homologous Urinary Bladder/metabolism Urogenital System/embryology,transplantation

Chemicals

Receptors, Androgen Receptors, Steroid Dihydrotestosterone

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Cunha G R

Reese B A

Sekkingstad M

Article Info

Journal

Endocrinology

Abbr.

Endocrinology

ISSN

0013-7227

DOI

10.1210/endo-107-6-1767

Published

1980-12-00

Pages

1767-70

Language

English

Region

United States

NLM ID

0375040

Subset

Grants

NCI NIH HHS · N0 1-CP-75875 · United States

External Links

PubMed source DOI: 10.1210/endo-107-6-1767 View journal details

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Induction of nuclear androgen-binding sites in epithelium of the embryonic urinary bladder by mesenchyme of the urogenital sinus of embryonic mice.

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