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题目:: Local mitogenic effect of tissue mast cell secretion.
作者:: Franzén,Norrby(K)
状态:: 发布时间1980-12-18 , 更新时间 2006-11-15
期刊:: Cell Tissue Kinet
摘要:: The effect of drug-induced mast cell secretion on proliferation was studied in fibroblast-like and mesothelial-like cells in organ-cultured rat mesentery. Mast cell degranulation achieved by Compound 48/80 was followed by a marked mitogenic reaciton in the surrounding tissue cells. The drug itself lacked mitogenic effect on cultured guinea-pig mesentery, the mast cells of which are unresponsive to the drug, and on a human normal fibroblast-like cell line. In contrast, histamine at about 10-(10) M, a major mast cell component, induced marked mitogenesis in guinea-pig mesentery without causing degranulation of mast cells. It is concluded that secreting rat-tissue mast cells release a mitogenic factor or factors acting locally on nearby tissue cells.
语言:: eng
DOI:

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