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PMID: 7416236 Published · ppublish English Journal Article

Lipid accumulation and ultrastructural change within the aortic wall during early spontaneous atherogenesis.

The American journal of pathology ·Vol. 100 ·No. 3 ·1980-09-00 ·Pages 683-705

Hajjar DP, Wight TN, Smith SC

Abstract

To identify the initial period and type of lipid accumulation during spontaneous atherosclerosis, quantitative chromatographic profiles of major lipid classes in upper thoracic aortas (non-lesion areas) and celiac artery cushions (lesion areas) were obtained from atherosclerosis-susceptible White Carneau (WC) and atherosclerosis-resistant Show Racer (SR) pigeons from 1 day to 6 months of age. Thoracic aortas of WC and SR pigeons contained similar amounts of cholesterol, nonesterified fatty acids, triacylglycerols, cholesteryl esters, phospholipids, and hydrocarbon at each age studied. However, celiac sites in WCs contained more total lipid than corresponding SR sites at 6 weeks and 6 months of age. This initial increase at 6 weeks in WCs was characterized by invreased concentrations of nonesterified saturated fatty acids. By 6 months of age, WC celiac cushions had greater concentrations of each lipid class except hydrocarbon than did SR cushions. This initial lipid accumulation was accompanied by ultrastructural changes within the arterial wall, which included the presence of extracellular, vesiclelike structures and extensive accumulation of basal lamina-like material between cells. This material was not present in aortic regions that are not predisposed to lesion formation. This material increased by 6 months of age in the enlarging WC fibromuscular intimal cushions. These morphologic changes paralleled the quantitative lipid increases and represented the first morphologic changes detectable at this site. Age-related changes in arterial lipid content and ultrastructure in SRs are different from those related to early spontaneous atherogenesis in WCs.

MeSH Terms
Age Factors Animals Aorta/ultrastructure Aorta, Thoracic/metabolism Arteriosclerosis/metabolism,pathology Celiac Artery/metabolism,ultrastructure Cholesterol/metabolism Cholesterol Esters/metabolism Columbidae Fatty Acids, Nonesterified/metabolism Hydrocarbons/metabolism Lipid Metabolism Phospholipids/metabolism Triglycerides/metabolism
Chemicals
Cholesterol Esters Fatty Acids, Nonesterified Hydrocarbons Phospholipids Triglycerides Cholesterol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hajjar D P
Wight T N
Smith S C
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1980-09-00
Pages
683-705
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1903566
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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