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PMID: 7410838 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 125 ·No. 3 ·1980-09-00 ·Pages 1256-61

Russell JH, Dobos CB

Abstract

Within minutes of CTL-target interaction, the intracellular disintegration of the target cell nucleus begins. This nuclear event satisfies the ionic and temperature requirements that have been described by others as important in CTL-mediated lysis. Such nuclear disintegration does not occur in Ab+C-lysed targets. Thus the target cell nucleus appears to signal a primary event in CTL-mediated lysis that distinguishes the CTL lytic mechanism from that of Ab+C.

MeSH Terms

Animals Antibodies Calcium/metabolism Cell Communication Cell Nucleus/immunology Complement System Proteins Cytotoxicity, Immunologic Magnesium/metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Polyethylene Glycols/pharmacology Rabbits Solubility Time Factors Uridine/metabolism

Chemicals

Antibodies Polyethylene Glycols Complement System Proteins Magnesium Calcium Uridine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Russell J H

Dobos C B

Article Info

Journal

Journal of immunology (Baltimore, Md. : 1950)

Abbr.

J Immunol

ISSN

0022-1767

Published

1980-09-00

Pages

1256-61

Language

English

Region

United States

NLM ID

2985117R

Subset

External Links

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Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.

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