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PMID: 7400754 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments.

The Journal of experimental medicine ·Vol. 152 ·No. 1 ·1980-07-01 ·Pages 113-23

Morgan EL, Walker SM, Thoman ML, Weigle WO

Abstract

Fc fragments derived from human and murine Ig were found to be potent adjuvants when administered with antigen. Both the in vivo and in vitro anti- sheep erythrocytes (SRBC) responses were significantly enhanced by Fc fragments. The adjuvant effect was shown to be extremely dependent upon the dose of antigen used, with the greatest enhancement occurring when suboptimal doses of antigen are employed. The anti-genicity of the Fc molecule was not related to its adjuvanticity because homologous Fc was as potent an adjuvant as heterologous Fc. Moreover, human Fc fragments enhanced anti-SRBC responses in mice which were tolerant to human gamma globulin.

MeSH Terms
Adjuvants, Immunologic/pharmacology Animals Antibody Formation Cells, Cultured Erythrocytes/immunology Immunoglobulin Fc Fragments/immunology Immunoglobulin G/immunology Male Mice Sheep Spleen/immunology
Chemicals
Adjuvants, Immunologic Immunoglobulin Fc Fragments Immunoglobulin G
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Morgan E L
Walker S M
Thoman M L
Weigle W O
References (30)
30 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.152.1.113
Published
1980-07-01
Pages
113-23
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185893
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.152.1.113 PMC Full Text View journal details
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