Specific calcium-dependent release of endogenous glutamate from rat striatum is reduced by destruction of the cortico-striatal tract.

Experimental brain research ·Vol. 39 ·No. 2 ·1980-00-00 ·Pages 239-40

Rowlands GJ, Roberts PJ

Abstract

Rat neostriatal slices exhibited a Ca2+-dependent release of endogenous glutamate when depolarized by elevated K+. This evoked release was reduced by 30% in tissue from animals subjected to fronto-parietal lesions 3 weeks previously. These results support the proposal that glutamate is the transmitter of the cortico-striatal pathway.

MeSH Terms

Animals Calcium/pharmacology Cerebral Cortex/physiology Corpus Striatum/drug effects,metabolism Glutamates/metabolism Neural Pathways/physiology Rats

Chemicals

Glutamates Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rowlands G J

Roberts P J

References (7)

7 references, click to expand

A glutamatergic corticostriatal path?
Brain Res. 1977 Jun 10;128(2):369-73 PMID: 871919
Fluorometric determination of aspartate, glutamate, and gamma-aminobutyrate in nerve tissue using enzymic methods.
Anal Biochem. 1966 Jun;15(3):487-97 PMID: 4381042
Stimulus evoked increase in the biosynthesis of the putative neurotransmitter glutamate in the hippocampus.
Brain Res. 1978 Mar 31;143(3):549-55 PMID: 25693
Glutamate release in vitro from corticostriatal terminals.
Brain Res. 1979 Oct 26;176(1):185-8 PMID: 487175
High affinity uptake of glutamate in terminals of corticostriatal axons.
Nature. 1977 Mar 24;266(5600):377-8 PMID: 859607
Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester: evidence for glutamic acid as an excitatory transmitter in the rat striatum.
Brain Res. 1976 Jan 30;102(1):91-101 PMID: 1247881
Effect of frontal cortex ablation on striatal glutamic acid level in rat.
Brain Res. 1977 Aug 26;132(2):370-4 PMID: 890487

Article Info

Journal

Experimental brain research

Abbr.

Exp Brain Res

ISSN

0014-4819

DOI

10.1007/BF00237555

Published

1980-00-00

Pages

239-40

Language

English

Region

Germany

NLM ID

0043312

Subset

External Links

PubMed source DOI: 10.1007/BF00237555 View journal details

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Specific calcium-dependent release of endogenous glutamate from rat striatum is reduced by destruction of the cortico-striatal tract.

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