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PMID: 7395868 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Linkage relationships and multipoint mapping of the human parotid salivary proteins (Pr, Pa, Db).

American journal of human genetics ·Vol. 32 ·No. 4 ·1980-07-00 ·Pages 555-63

Yu PL, Karn RC, Merritt AD, Azen EA, Conneally PM

Abstract

Based on data from 76 informative families, linkages between Pa and Pr and between Pr and Db have been established by two-point linkage analysis. In both pairs of loci, there were no significant sex heterogeneity in recombination fractions. Linkage between Pa and Db cannot be established based on two-point analyses, but a significant sex difference in the recombination fraction between Pa and Db was observed. Strong confirming evidence was obtained from three-point analysis to place Pa, Pr, and Db in one linkage group. The most likely order is Pa-Pr-Db, but the relative odds over second order Pr-Pa-Db are small. Haplotype frequencies of Pr, Pa, and Db were obtained based on the phenotypes of the 685 random Caucasians, providing evidence for marked linkage disequilibrium among the three loci.

MeSH Terms

Chromosome Mapping Gene Frequency Genetic Linkage Humans Parotid Gland/analysis Phenotype Polymorphism, Genetic Recombination, Genetic Salivary Proteins and Peptides/genetics Sex Factors

Chemicals

Salivary Proteins and Peptides

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Yu P L

Karn R C

Merritt A D

Azen E A

Conneally P M

References (13)

13 references, click to expand

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Genetic polymorphism of proline-rich human salivary proteins.
Science. 1973 Jun 8;180(4090):1067-9 PMID: 4706325
Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.
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Immunological relationships and a genetic interpretation of major and minor acidic proteins in human parotid saliva.
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[Studies of genetic markers in human saliva. (I). Frequencies of Pa and Pb systems from parotid saliva of Japanese in Tokyo].
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Linkage relationships of the proline-rich salivary proteins (Pr, Pa, Db).
Cytogenet Cell Genet. 1978;22(1-6):655-8 PMID: 752561
Differential elution of histones from gel-trapped nuclei.
Biopolymers. 1969;7(1):39-58 PMID: 5772420
Genetic polymorphism of human salivary proline-rich proteins: further genetic analysis.
Biochem Genet. 1974 Aug;12(2):109-20 PMID: 4424642
Genetic polymorphism of the major parotid salivary glycoprotein (Gl) with linkage to the genes for Pr, Db, and Pa.
Biochem Genet. 1979 Apr;17(3-4):257-79 PMID: 486071
Partial purification and characterization of a polymorphic protein (Pa) in human parotid saliva.
Am J Hum Genet. 1975 May;27(3):304-14 PMID: 803013
Genetic polymorphisms of human parotid salivary proteins (Pa, Pb, Pr, Db and Pm) and salivary amylase isozyme in Japanese population.
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Genetic polymorphism of basic proteins from parotid saliva.
Science. 1972 May 12;176(4035):673-4 PMID: 17778168

Article Info

Journal

American journal of human genetics

Abbr.

Am J Hum Genet

ISSN

0002-9297

Published

1980-07-00

Pages

555-63

Language

English

Region

United States

NLM ID

0370475

PMCID

PMC1686124

Subset

External Links

PubMed source PMC Full Text View journal details

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Linkage relationships and multipoint mapping of the human parotid salivary proteins (Pr, Pa, Db).

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