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LiteratureArticle Details
PMID: 7384811
Published · ppublish
English
Journal Article
Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro.
Abstract
Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.
MeSH Terms
Animals
Endorphins/pharmacology
Enkephalin, Methionine/analogs & derivatives
Enkephalins/pharmacology
Guinea Pigs
Locus Coeruleus/drug effects,physiology
Membrane Potentials/drug effects
Morphine Derivatives/pharmacology
Naloxone/pharmacology
Neurons/drug effects,physiology
Chemicals
Endorphins
Enkephalins
Morphine Derivatives
Naloxone
Enkephalin, Methionine
enkephalin-Met, Ala(2)-
normorphine
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1980-07-18
Pages
394-5
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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