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PMID: 738406 Published · ppublish English Journal Article

Interaction between azapropazone and warfarin.

Experientia ·Vol. 34 ·No. 10 ·1978-10-15 ·Pages 1320-1

McElnay JC, D'Arcy PF

Abstract

In vitro studies, using 2 separate techniques, have shown that the anti-inflammatory agent azapropazone caused displacement of warfarin from its plasma albumin binding and it is therfore suggested that such a displacement mechanism may be involved in the reported clinical interaction between these 2 drugs.

MeSH Terms
Apazone/blood,pharmacology Binding, Competitive Drug Interactions Humans Protein Binding Serum Albumin/metabolism Triazines/pharmacology Warfarin/blood,pharmacology
Chemicals
Serum Albumin Triazines Warfarin Apazone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McElnay J C
D'Arcy P F
References (7)
7 references, click to expand
  1. Interaction between azapropazone and warfarin.
    Br Med J. 1977 Sep 17;2(6089):773-4 PMID: 912313
  2. Displacement of warfarin from human albumin by diazoxide and ethacrynic, mefenamic, and nalidixic acids.
    Clin Pharmacol Ther. 1970 Jul-Aug;11(4):524-9 PMID: 5429179
  3. Interaction between azapropazone and warfarin.
    Br Med J. 1977 May 7;1(6070):1193-4 PMID: 861532
  4. Potentiation of anticoagulant effect of warfarin by phenylbutazone.
    N Engl J Med. 1967 Mar 2;276(9):496-501 PMID: 6018280
  5. Drug displacement of warfarin from human serum albumin: a fluorometric analysis.
    Toxicol Appl Pharmacol. 1975 Aug;33(2):267-75 PMID: 1237182
  6. Drug therapy. Binding of drugs to serum albumin (second of two parts).
    N Engl J Med. 1976 Mar 4;294(10):526-31 PMID: 765821
  7. Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone.
    J Clin Invest. 1974 Jun;53(6):1607-17 PMID: 4830225
Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01981445
Published
1978-10-15
Pages
1320-1
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01981445
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