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PMID: 7378069 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.

The Biochemical journal ·Vol. 186 ·No. 2 ·1980-02-15 ·Pages 621-4

Williamson DH, Ilic V, Tordoff AF, Ellington EV

Abstract

Vasopressin (10nM) inhibited ketogenesis (56%) in hepatocytes from fed rats when oleate (1 mM) was the substrate, but had no effect with butyrate (10mM). The hormone increased the accumulation of lactate and stimulated the esterification of [1(-14)C]oleate (70%). These effects of vasopressin were reversed by glucagon (10 nM). The physiological implications of these findings are discussed.

MeSH Terms
Animals Butyrates/metabolism Drug Interactions Female Glucagon/pharmacology Glucose/biosynthesis In Vitro Techniques Ketone Bodies/biosynthesis Lactates/biosynthesis Liver/cytology,drug effects,metabolism Oleic Acids/metabolism Rats Vasopressins/pharmacology
Chemicals
Butyrates Ketone Bodies Lactates Oleic Acids Vasopressins Glucagon Glucose
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Williamson D H
Ilic V
Tordoff A F
Ellington E V
References (26)
26 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1860621
Published
1980-02-15
Pages
621-4
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1161618
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1860621 PMC Full Text View journal details
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