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PMID: 7350525 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

A UGA termination suppression tRNATrp active in rabbit reticulocytes.

Nature ·Vol. 283 ·No. 5742 ·1980-01-03 ·Pages 41-6

Geller AI, Rich A

Abstract

A tRNATrp was purified from rabbit reticulocytes which suppresses the UGA termination codon of beta-haemoglobin mRNA. Evidence is presented that the beta-haemoglobin readthrough protein is found in reticulocyte translations and intact cells. Some natural readthrough proteins perform essential functions; they are synthesised through suppression of UGA or UAG but not UAA termination codons.

MeSH Terms

Animals Codon Globins/genetics Molecular Weight Peptide Chain Termination, Translational Peptide Fragments/analysis RNA, Messenger/genetics RNA, Transfer/genetics Rabbits Reticulocytes/metabolism Suppression, Genetic Tryptophan

Chemicals

Codon Peptide Fragments RNA, Messenger Tryptophan Globins RNA, Transfer

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Geller A I

Rich A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/283041a0

Published

1980-01-03

Pages

41-6

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/283041a0 View journal details

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A UGA termination suppression tRNATrp active in rabbit reticulocytes.

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