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PMID: 7338482 Published · ppublish English Journal Article

The mucin profiles of normal gastric mucosa, intestinal metaplasia and its variants and gastric carcinoma.

The Histochemical journal ·Vol. 13 ·No. 6 ·1981-11-00 ·Pages 931-9

Jass JR, Filipe MI

Abstract

Human gastrectomy specimens, including 48 carcinomas and 25 selected benign cases showing extensive intestinal metaplasia (IM), were examined in detail histologically and histochemically. IM was classified into complete (type I), incomplete without sulphomucins (type IIA) and incomplete with sulphomucins (type IIB). Type IIB was associated with 'intestinal' but not 'diffuse' cancers (P less than 0.01) or benign lesions (P less than 0.01). The mucin profiles of IIB IM were similar to 'intestinal' cancers with sulphomucins predominating over N-acetylsialomucins. O-acetylsialomucins were not seen in IIB IM or tumours but were observed in complete or type I IM. These findings suggest a histogenic link between incomplete IM secreting sulphomucins (or 'colonic' metaplasia) and 'intestinal' cancers of the human stomach.

MeSH Terms
Epithelial Cells Gastric Mucosa/cytology Humans Intestines/pathology Mucins/analysis Stomach Neoplasms/pathology
Chemicals
Mucins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jass J R
Filipe M I
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31 references, click to expand
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Article Info
Journal
The Histochemical journal
Abbr.
Histochem J
ISSN
0018-2214
DOI
10.1007/BF01002633
Published
1981-11-00
Pages
931-9
Language
English
Region
Netherlands
NLM ID
0163161
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01002633
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