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PMID: 7337708 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibition of lipid peroxidation by the iron-binding protein lactoferrin.

The Biochemical journal ·Vol. 199 ·No. 1 ·1981-10-01 ·Pages 259-61

Gutteridge JM, Paterson SK, Segal AW, Halliwell B

Abstract

Lactoferrin containing physiological amounts of iron is an inhibitor of lipid peroxidation induced by iron(III) salts and ascorbic acid. It might therefore help to protect neutrophils, inflammatory foci and secretions from metal-ion-dependent oxidative damage.

MeSH Terms

Animals Ascorbic Acid/pharmacology Cattle Ferric Compounds/pharmacology Humans Lactoferrin/metabolism,pharmacology Lactoglobulins/pharmacology Lipid Metabolism Liposomes/metabolism Protein Binding Proteins/pharmacology

Chemicals

Ferric Compounds Lactoglobulins Liposomes Proteins Lactoferrin Ascorbic Acid

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Gutteridge J M

Paterson S K

Segal A W

Halliwell B

References (13)

13 references, click to expand

Metal-combining properties of human lactoferrin (red milk protein). 1. The involvement of bicarbonate in the reaction.
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The effect of serum and experimental variables on the transferrin and reticulocyte interaction.
Biochim Biophys Acta. 1975 Aug 13;399(2):254-64 PMID: 1174530
Evidence for superoxide-dependent reduction of Fe3+ and its role in enzyme-generated hydroxyl radical formation.
Chem Biol Interact. 1976 Sep;15(1):77-89 PMID: 183903
The measurement of malondialdehyde in peroxidised ox-brain phospholipid liposomes.
Anal Biochem. 1977 Sep;82(1):76-82 PMID: 907133
Oxygen-dependent microbial killing by phagocytes (first of two parts).
N Engl J Med. 1978 Mar 23;298(12):659-68 PMID: 24176
The production of hydroxyl and superoxide radicals by stimulated human neutrophils- measurements by EPR spectroscopy.
FEBS Lett. 1979 Apr 1;100(1):23-6 PMID: 220087
The role of lactoferrin in the bactericidal function of polymorphonuclear leucocytes.
Immunology. 1979 Apr;36(4):781-91 PMID: 108208
Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine.
Biochem J. 1979 Nov 15;184(2):469-72 PMID: 230833
Isolation of lactoferrin from human whey by a single chromatographic step.
FEBS Lett. 1980 Jan 14;109(2):180-3 PMID: 6766407
Iron in human milk.
J Pediatr. 1980 Mar;96(3 Pt 1):380-4 PMID: 7359228
Lactoferrin deficiency as a consequence of a lack of specific granules in neutrophils from a patient with recurrent infections. Detection by immunoperoxidase staining for lactoferrin and cytochemical electron microscopy.
Am J Pathol. 1980 May;99(2):413-28 PMID: 6155073
Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system.
J Clin Invest. 1981 Feb;67(2):352-60 PMID: 6780607
Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA.
Biochem J. 1981 Oct 1;199(1):263-5 PMID: 6175315

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1990259

Published

1981-10-01

Pages

259-61

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1163360

Subset

External Links

PubMed source DOI: 10.1042/bj1990259 PMC Full Text View journal details

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Inhibition of lipid peroxidation by the iron-binding protein lactoferrin.

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