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PMID: 7306008 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The activation of pyruvate dehydrogenase in the perfused rat heart by adrenaline and other inotropic agents.

The Biochemical journal ·Vol. 194 ·No. 2 ·1981-02-15 ·Pages 639-43

McCormack JG, Denton RM

Abstract

Adrenaline resulted in a reversible 4-fold increase in the amount of pyruvate dehydrogenase in its active non-phosphorylated form in the perfused rat heart within 1 min. The increase was less in extent in hearts from starved or diabetic rats or in hearts from control rats oxidizing acetate, unless pyruvate was added to the perfusion medium. Increases could also be induced by other inotropic agents, supporting the hypothesis that increases in cytoplasmic Ca2+ can be relayed into mitochondria and influence oxidative metabolism.

MeSH Terms
Animals Calcium/pharmacology Cardiotonic Agents/pharmacology Diabetes Mellitus, Experimental/metabolism Enzyme Activation/drug effects Epinephrine/pharmacology Glucagon/pharmacology Heart/drug effects In Vitro Techniques Isoproterenol/pharmacology Male Myocardium/enzymology Pyruvate Dehydrogenase Complex/metabolism Rats Starvation/metabolism
Chemicals
Cardiotonic Agents Pyruvate Dehydrogenase Complex Glucagon Isoproterenol Calcium Epinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
McCormack J G
Denton R M
References (17)
17 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1940639
Published
1981-02-15
Pages
639-43
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1162790
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1940639 PMC Full Text View journal details
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