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PMID: 730354 Published · ppublish English Comparative Study Journal Article

Comparative study of American cutaneous leishmaniasis and diffuse cutaneous leishmaniasis in two strains of inbred mice.

Infection and immunity ·Vol. 22 ·No. 2 ·1978-11-00 ·Pages 301-7

Pérez H, Arredondo B, González M

Abstract

Two Leishmania strains, AZV (isolated from a typical case of American cutaneous leishmaniasis) and AMP (from a case of diffuse cutaneous leishmaniasis), were studied in C57BL/6 and BALB/c mice. After infection with 10(4) amastigotes of either strain, C57BL/6 mice developed self-resolving lesions lasting 20 to 23 weeks and showed both delayed hypersensitivity response to leishmanial antigen and specific agglutinating antibodies. On the other hand, BALB/c mice infected with 10(4) AZV or AMP amastigotes developed chronic, large, ulcerated lesions and showed impaired cellular and humoral responses to the parasite. When BALB/c and C57BL/6 mice received 10(2) AMP amastigotes, patterns of infection were similar to those observed after inoculation of 10(4) amastigotes. In vitro studies revealed that spleen cells from AZV- or AMP-infected C57BL/6 mice showed an increased DNA-synthetic response to leishmanial antigen, concanavalin A, and phytohemagglutinin. Spleen cells from AZV- or AMP-infected BALB/c mice showed an increased response to concanavalin A and diminished responses to leishmanial antigen, phytohemagglutinin, and lipopolysaccharide.

MeSH Terms
Animals Antibody Formation Antigens/administration & dosage Female Hypersensitivity, Delayed In Vitro Techniques Leishmaniasis/immunology Leishmaniasis, Mucocutaneous/immunology Lymphocyte Activation Mice Mice, Inbred BALB C Mice, Inbred C57BL Mitogens/pharmacology Species Specificity
Chemicals
Antigens Mitogens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pérez H
Arredondo B
González M
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30 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.22.2.301-307.1978
Published
1978-11-00
Pages
301-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422153
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.22.2.301-307.1978 PMC Full Text View journal details
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