Isozyme variations in acetaldehyde dehydrogenase (e.c.1.2.1.3) in human tissues.

Human genetics ·Vol. 44 ·No. 2 ·1978-10-31 ·Pages 181-5

Harada S, Agarwal DP, Goedde HW

Abstract

NAD-dependent acetaldehyde dehydrogenase (ALDH) of human tissues was investigated by electrophoresis and enzyme assay. ALDH is located mainly in the liver and kidney. The isozymes consist of at least six different components. Five different phenotypes were found in a total of 68 human liver and kidney specimens. It is likely that three isozyme sets are concerned in determining ALDH types. The distribution of various phenotypes of ALDH isozyme sets is presented.

MeSH Terms

Aldehyde Oxidoreductases/genetics Electrophoresis, Starch Gel Genetic Variation Humans Isoenzymes/genetics Phenotype Tissue Distribution

Chemicals

Isoenzymes Aldehyde Oxidoreductases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Harada S

Agarwal D P

Goedde H W

References (7)

7 references, click to expand

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Human liver alcohol dehydrogenase isoenzyme variations. Improved separation methods using prolonged high voltage starch-gel electrophoresis and isoelectric focusing.
Hum Genet. 1978 Jan 19;40(2):215-20 PMID: 624549
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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00295411

Published

1978-10-31

Pages

181-5

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00295411 View journal details

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Isozyme variations in acetaldehyde dehydrogenase (e.c.1.2.1.3) in human tissues.

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