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PMID: 7299345 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.

The Journal of experimental medicine ·Vol. 154 ·No. 5 ·1981-11-01 ·Pages 1517-24

Trowbridge IS, Omary MB

Abstract

Monoclonal antibodies have been obtained that react with the murine leukocyte surface glycoproteins bearing the macrophage differentiation antigen Mac-1. Structural and antigenic analysis shows that related glycoproteins are found on other murine hematopoietic cell types. The data not only illustrate the complexity of cell surface structures that can be detected by means of monoclonal antibodies, but also raise questions as to the functional significance of this family of molecules within the hematopoietic system.

MeSH Terms
Animals Antibodies, Monoclonal Antigens, Surface Chemical Precipitation Glycoproteins/immunology Leukocytes/immunology Macromolecular Substances Macrophages/immunology Membrane Proteins/immunology Mice Mice, Inbred Strains Molecular Weight
Chemicals
Antibodies, Monoclonal Antigens, Surface Glycoproteins Macromolecular Substances Membrane Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Trowbridge I S
Omary M B
References (21)
21 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.154.5.1517
Published
1981-11-01
Pages
1517-24
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186511
Subset
IM
Grants
NCI NIH HHS · CA 09370 · United States
NCI NIH HHS · CA 17733 · United States
External Links
PubMed source DOI: 10.1084/jem.154.5.1517 PMC Full Text View journal details
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