Home LiteratureArticle Details
PMID: 7298391 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

NADP-dependent dehydrogenases in rat liver parenchyma. III. The description of a liponeogenic area on the basis of histochemically demonstrated enzyme activities and the neutral fat content during fasting and refeeding.

Histochemistry ·Vol. 72 ·No. 4 ·1981-00-00 ·Pages 579-615

Rieder H

Abstract

The activities of glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase(6PGDH), malic enzyme (ME) and isocitrate dehydrogenase (ICDh) were investigated with optimized histochemical methods (Rieder it al 1978), and the activity of 3-hydroxybutyrate dehydrogenase (3HBDH) and neutral fat content with conventional techniques in the liver of male rats under the following experimental dietary conditions: (A) Fasting for 0, 12 and 84h; (B) 84-h fasting followed by refeeding with a low-fat, high-carbohydrate diet for 6 h and for 2, 3, 5, 7, 11 and 14 nights; (C) refeeding with standard diet for 5 nights; (D) low-fat high-carbohydrate diet for 7 an 14 nights. The activities of G6PDH, 6PGDH and ME decreased slightly during fasting primarily in zone 1 and increased dramatically on refeeding with a low-fat, high-carbohydrate diet. This activity increase was confined mainly to zone 3 during the first 3 days and was accompanied by a deposition of neutral fats that began in zone 3 and progressed to zone 1. Neutral for accumulation was maximal after 3 nights, with a uniform accumulation of large droplets in all the hepatocytes; this was followed by a release that started in zone 3 and proceeded in a periportal direction. On the other hand, G6PDH, 6PGDH and ME attained their maximum activities after 5 amd 7 nights of low-fat diet, the activities being nearly homogeneously distributed over the liver acinus in a few cases. Subsequently the activities fill mainly in zone 1, causing the activity patterns and levels to approach those of the animals in group (D). In contrast to this, the activity of ICDH increased during fasting principally in zone 1, so that the otherwise steep activity gradient in favor of zone 3 lessened. Refeeding led at first to a fall of activity below the initial value, but later the normal distribution pattern was restored. The activity of 3HBDH showed a behavior similar to that of ICDH. The findings are discussed with reference to the functional heterogeneity of the liver parenchyma, and the existence of a liponeogenic area in zone 3 is proposed.

MeSH Terms
Animals Dietary Fats/metabolism Fasting Food Glucosephosphate Dehydrogenase/metabolism Histocytochemistry Hydroxybutyrate Dehydrogenase/metabolism Isocitrate Dehydrogenase/metabolism Lipid Metabolism Liver/enzymology Malate Dehydrogenase/metabolism Male NADH, NADPH Oxidoreductases/isolation & purification NADPH Dehydrogenase/isolation & purification Phosphogluconate Dehydrogenase/metabolism Rats Rats, Inbred Strains
Chemicals
Dietary Fats Hydroxybutyrate Dehydrogenase Malate Dehydrogenase Isocitrate Dehydrogenase Phosphogluconate Dehydrogenase Glucosephosphate Dehydrogenase NADH, NADPH Oxidoreductases NADPH Dehydrogenase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rieder H
References (166)
166 references, click to expand
  1. Ethionine fatty liver.
    Adv Lipid Res. 1967;5:119-83 PMID: 4866070
  2. Hormonal regulation of glucokinase in primary cultures of adult rat hepatocytes.
    J Biol Chem. 1979 Dec 25;254(24):12331-6 PMID: 115884
  3. The effects of nutritional and hormonal factors on the fatty acid synthetase level of rat liver.
    J Biol Chem. 1969 Aug 25;244(16):4510-6 PMID: 5806590
  4. ON THE RESPONSE OF HEPATIC GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY TO CHANGES IN DIET COMPOSITION AND FOOD INTAKE PATTERN.
    Adv Enzyme Regul. 1963;1:121-36 PMID: 14190349
  5. Plasma lipid levels and systolic blood pressure in ovariectomized and intact rats treated with contraceptive and other sex steroids.
    Artery. 1980;6(4):307-19 PMID: 7396728
  6. The effect of phenobarbitone on the production of type I hydrogen from reduced nicotinamide-adenine phosphate in different regions of the liver lobule.
    Biochem J. 1971 Nov;125(2):22P-23P PMID: 4401375
  7. Very low density lipoprotein synthesis and secretion by cultured rat hepatocytes.
    J Biol Chem. 1979 Mar 25;254(6):2010-6 PMID: 217875
  8. Subdivision of hexagonal liver lobules into a structural and functional unit; role in hepatic physiology and pathology.
    Anat Rec. 1954 May;119(1):11-33 PMID: 13180999
  9. The effect of phenobarbitone on cytoplasmic NADP-linked dehydrogenase activities in rat liver.
    Biochim Biophys Acta. 1978 Feb 13;539(1):12-8 PMID: 623789
  10. Leucine and D-3-hydroxybutyrate as lipid precursors in developing rat spinal cord and liver.
    Biochem J. 1976 Aug 15;158(2):501-4 PMID: 985444
  11. Sex-related differences in biotransformation of aniline hydroxylase in Sprague-Dawley rats.
    Pharmacology. 1979;18(1):52-6 PMID: 419161
  12. Effects of phenobarbital, pregnenolone-16 alpha-carbonitrile, and 3-methylcholanthrene pretreatments on the distribution of NADPH-cytochrome c (P-450) reductase within the liver lobule.
    Mol Pharmacol. 1980 Sep;18(2):304-12 PMID: 6775183
  13. Active oxygen species and the functions of phagocytic leukocytes.
    Annu Rev Biochem. 1980;49:695-726 PMID: 6250449
  14. NADP-dependent dehydrogenases in rat liver parenchyma. II. Comparison of qualitative and quantitative G6PDH distribution patterns with particular reference to sex differences.
    Histochemistry. 1979 Feb 26;60(1):43-52 PMID: 429212
  15. Heterogeneous reciprocal localization of fructose-1,6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue.
    FEBS Lett. 1977 Nov 15;83(2):272-6 PMID: 201494
  16. THE QUANTITATIVE HISTOCHEMISTRY OF THE NORMAL HUMAN LIVER LOBULE.
    J Lab Clin Med. 1965 Feb;65:248-56 PMID: 14267250
  17. Rat liver glucose 6-phosphate dehydrogenase. Regulation by carbohydrate diet and insulin.
    J Biol Chem. 1971 Mar 10;246(5):1249-54 PMID: 5545067
  18. Factors involved in changes in hepatic lipogenesis during development of the rat.
    Biochem J. 1970 Jun;118(1):155-62 PMID: 4248618
  19. Electrophoretic separation of the magnesium-dependent glucose 6-phosphate dehydrogenases in rats.
    J Histochem Cytochem. 1967 Jul;15(7):419-20 PMID: 6051745
  20. Enzyme histochemistry as a link between biochemistry and morphology.
    Prog Histochem Cytochem. 1976;8(2):1-68 PMID: 186846
  21. [Quantitative and qualitative electron microscopic studies of the structure of the liver lobule of noral rats].
    Z Zellforsch Mikrosk Anat. 1968;89(2):225-40 PMID: 5749107
  22. Compartmentation of NADPH in rat liver.
    Arch Biochem Biophys. 1977 Apr 15;180(1):69-74 PMID: 16569
  23. Histochemical demonstration of enzymes in rat liver during post-natal development. Enzymes related to NADPH-dependent hydroxylating systems and to sex difference.
    Histochemie. 1970;23(1):71-81 PMID: 5455071
  24. New histochemical techniques for the demonstration of tissue oxidase (cytochrome oxidase).
    J Histochem Cytochem. 1959 Mar;7(2):112-22 PMID: 13664949
  25. The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver.
    Biochem J. 1967 May;103(2):514-27 PMID: 4291787
  26. Microphotometric studies on intraacinar enzyme distribution in rat liver.
    Histochemistry. 1979 Nov;64(1):23-33 PMID: 521313
  27. Regulation of pentose phosphate pathway dehydrogenases by NADP+/NADPH ratios.
    Biochem Biophys Res Commun. 1976 Jan 26;68(2):436-41 PMID: 3177
  28. Effects of ethynyloestradiol on the metabolism of [1-14C]oleate by perfused livers and hepatocytes from female rats.
    Biochem J. 1979 May 15;180(2):265-71 PMID: 226070
  29. Workshop on regulation of hepatic cholesterol and bile acid metabolism.
    J Lipid Res. 1980 May;21(4):496-500 PMID: 7381339
  30. The effect of dietary carbohydrate and fat on the synthesis of rat liver 6-phosphogluconate dehydrogenase.
    Biochim Biophys Acta. 1971 Nov 12;252(2):305-13 PMID: 5133531
  31. A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells.
    J Cell Biol. 1968 Apr;37(1):27-46 PMID: 5645844
  32. Proceedings: The mechanism of hypertriglyceridaemia in oestrogen-treated rats.
    J Endocrinol. 1974 Nov;63(2):58P PMID: 4155423
  33. Studies on the optimalisation and standardisation of the light microscopical succinate dehydrogenase histochemistry.
    Histochemistry. 1978 Aug 15;57(1):47-60 PMID: 689925
  34. The effect of fasting and refeeding on the composition and synthesis of triacylglycerols, phosphatidylcholines, and phosphatidylethanolamines in rat liver.
    Arch Biochem Biophys. 1979 Nov;198(1):287-95 PMID: 507846
  35. [The intracellular distribution of DPN- and TPN-specific isocitrate dehydrogenase].
    Enzymol Biol Clin (Basel). 1967;8(3):161-75 PMID: 4383622
  36. Utlization of D-3-hydroxy[3-14C]butyrate for lipogenesis in vivo in lactating rat mammary gland.
    Biochem J. 1978 Nov 15;176(2):635-8 PMID: 33671
  37. The role of 3-oxo acid-CoA transferase in the regulation of ketogenesis in the liver.
    FEBS Lett. 1979 Jul 15;103(2):212-5 PMID: 38142
  38. Acetoacetyl-CoA synthetase; a lipogenic enzyme in rat tissues.
    FEBS Lett. 1975 Dec 1;60(1):7-10 PMID: 1227960
  39. Quantitation of messenger RNA levels for rat liver 6-phosphogluconate dehydrogenase.
    J Biol Chem. 1978 Jan 10;253(1):52-7 PMID: 618866
  40. Influence of dietary cholesterol and cholic acid on liver carbohydrate metabolism enzymes in rats.
    J Nutr. 1973 Jan;103(1):93-101 PMID: 4682455
  41. Changes in the hepatic levels of messenger ribonucleic acid for malic enzyme during induction by thyroid hormone or diet.
    Biochemistry. 1980 Feb 5;19(3):579-85 PMID: 7356948
  42. Lactate production in the perfused rat liver.
    Biochem J. 1971 Nov;125(1):129-39 PMID: 5158899
  43. Glucose dehydrogenase (hexose 6-phosphate dehydrogenase) and the microsomal electron transport system. Evidence supporting their possible functional relationship.
    J Biochem. 1979 Feb;85(2):319-26 PMID: 422533
  44. Nuclear volume and cellular metabolism.
    Adv Anat Embryol Cell Biol. 1980;60:1-54 PMID: 6992523
  45. Lipogenesis from ketone bodies in rat brain. Evidence for conversion of acetoacetate into acetyl-coenzyme A in the cytosol.
    Biochem J. 1976 Jun 15;156(3):603-7 PMID: 949342
  46. Relationship of malic enzyme activity to fatty acid synthesis and the pathways of glucose catabolism in developing rat liver.
    J Nutr. 1980 Jan;110(1):90-9 PMID: 7354390
  47. Prevention of dietary induction of rat liver glucose-6-phosphate dehydrogenase by cyclic adenosine 3'.5'-monophosphate and its elimination by glucose prefeeding.
    Enzyme. 1976;21(5):436-47 PMID: 182484
  48. Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate.
    Eur J Biochem. 1979 Jun;97(1):283-95 PMID: 38961
  49. Pathways of NADPH in rat liver. Evidence favoring a single cytosolic pool.
    Arch Biochem Biophys. 1980 Jan;199(1):140-6 PMID: 7356326
  50. [Pathogenesis, diagnosis and therapy of fatty liver].
    Med Welt. 1973 May 25;24(21):862-5 PMID: 4784335
  51. Identification and quantitation of polysomes synthesizing rat liver fatty acid synthetase during nutritional or hormonal regulation.
    Int J Biochem. 1979;10(10):791-6 PMID: 510660
  52. Mixed function oxidation in perfused rat liver. The effect of aminopyrine on oxygen uptake.
    Eur J Biochem. 1969 Oct;10(3):459-67 PMID: 4390651
  53. Regulation of malic enzyme synthesis by insulin triiodothyronine, and glucagon in liver cells in culture.
    J Biol Chem. 1976 May 25;251(10):3027-32 PMID: 944696
  54. Immunological titration of rat liver glucose-6-phosphate dehydrogenase from animals fed high and low carbohydrate diets.
    Biochem Biophys Res Commun. 1975 Oct 27;66(4):1106-11 PMID: 1191279
  55. A preliminary investigation of the hormonal control of the hexose monophosphate oxidative pathway.
    Biochem J. 1955 Nov;61(3):390-7 PMID: 13269373
  56. Distribution and some properties of NADPH and NADH oxidase in parenchymal and nonparenchymal liver cells.
    Arch Biochem Biophys. 1977 Feb;179(1):8-14 PMID: 14596
  57. Sex-related differences in diurnal activities and development of hepatic microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7alpha-hydroxylase.
    Biochim Biophys Acta. 1978 Oct 25;531(1):115-24 PMID: 568487
  58. Regulation of ATP-citrate lyase in primary cultures of adult rat hepatocytes.
    J Biol Chem. 1979 Dec 10;254(23):12169-73 PMID: 115879
  59. Factors controlling the flux of glucose through the pentose phosphate pathway.
    Postgrad Med J. 1971 Jun;47:Suppl:403-6 PMID: 4397783
  60. Studies on microsomal glucose-6-phosphate dehydrogenase of rat liver.
    J Biochem. 1972 Jun;71(6):1009-14 PMID: 4342280
  61. Dietary regulation of 6-phosphogluconate dehydrogenase synthesis.
    J Biol Chem. 1976 Jun 25;251(12):3539-44 PMID: 931998
  62. Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver.
    Biochem J. 1968 Jul;108(3):353-61 PMID: 5667251
  63. Metabolic interactions between hepatic fatty acid oxidation and gluconeogenesis in the newborn rat [proceedings].
    Biochem Soc Trans. 1978;6(6):1323-4 PMID: 217782
  64. Regulation of the pentose phosphate cycle.
    Biochem J. 1974 Mar;138(3):425-35 PMID: 4154743
  65. H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.
    J Clin Invest. 1975 May;55(5):945-55 PMID: 1123431
  66. The hexosemonophosphate shunt and adaptive hyperlipogenesis.
    Diabetes. 1958 Nov-Dec;7(6):478-85 PMID: 13597742
  67. Regulation of hepatic fatty acid oxidation and ketone body production.
    Annu Rev Biochem. 1980;49:395-420 PMID: 6157353
  68. Citrate cleavage in adipose tissue.
    Proc Natl Acad Sci U S A. 1965 Sep;54(3):899-904 PMID: 4379378
  69. Identification of G6PDH-active sinusoidal cells as Kupffer cells in the rat liver.
    Cell Tissue Res. 1979 Feb 15;196(2):237-47 PMID: 421255
  70. [Glucose-6-phosphate dehydrogenase from rat liver. II. Effect of diet on enzyme activity in vivo, and inhibition by long chain fatty acids in vitro].
    J Biochem. 1967 May;61(5):541-9 PMID: 6059954
  71. Changes in patterns of enzymes of carbohydrate metabolism in the developing rat liver.
    J Biol Chem. 1963 Jul;238:2267-73 PMID: 14016891
  72. Coordinate control of rat liver lipogenic enzymes by insulin.
    Arch Biochem Biophys. 1974 Jun;162(2):340-4 PMID: 4152087
  73. Apparent unbalance between the activities of 6-phosphogluconate and glucose-6-phosphate dehydrogenases in rat liver.
    Biochem Biophys Res Commun. 1973 Jan 4;50(1):179-85 PMID: 4683622
  74. Hormonal regulation of fatty acid synthetase, acetyl-CoA carboxylase and fatty acid synthesis in mammalian adipose tissue and liver.
    Biochim Biophys Acta. 1975 Mar 24;380(3):454-72 PMID: 237534
  75. PATTERNS OF DIETARY AND HORMONAL INDUCTION OF CERTAIN NADP-LINKED LIVER ENZYMES.
    Am J Physiol. 1964 Feb;206:357-61 PMID: 14120443
  76. Further studies on the properties and assay of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver.
    Biochem J. 1953 Oct;55(3):400-8 PMID: 13105646
  77. The regulation of triglyceride synthesis and fatty acid synthesis in rat epididymal adipose tissue. Effects of altered dietary and hormonal conditions.
    Biochem J. 1970 Sep;119(2):221-42 PMID: 4249859
  78. Regulation of hepatic acetyl coenzyme A carboxylase by insulin and glucagon.
    J Biol Chem. 1979 Jul 25;254(14):6644-9 PMID: 36401
  79. Dehydrogenase histochemistry of lipid-rich tissues: a tetrazolium-mental chelation technique to improve localization.
    Histochem J. 1979 Jul;11(4):485-8 PMID: 91595
  80. Regulation of rat liver glucose 6- phosphate dehydrogenase levels by adenosine 3', 5' -monophosphate.
    J Biol Chem. 1971 Dec 25;246(24):7823-4 PMID: 4332567
  81. A study of drug metabolism linked to cytochrome P-450 in isolated rat-liver cells.
    Eur J Biochem. 1974 Jul 15;46(2):351-60 PMID: 4152752
  82. The regulation of the release of ketone bodies by the liver.
    Adv Enzyme Regul. 1966;4:339-54 PMID: 4865971
  83. Hexokinase and glucokinase distribution in the liver lobule.
    J Histochem Cytochem. 1980 Jun;28(6):579-81 PMID: 7391551
  84. The isolation and characterization of a bile ductule cell population from normal and bile-duct ligated rat livers.
    Br J Exp Pathol. 1977 Jun;58(3):301-10 PMID: 326290
  85. The distribution of hepatic metabolites and the control of the pathways of carbohydrate metabolism in animals of different dietary and hormonal status.
    Arch Biochem Biophys. 1971 Apr;143(2):617-63 PMID: 4397678
  86. Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain.
    Biochem J. 1973 Mar;132(3):653-6 PMID: 4724596
  87. D-beta-Hydroxybutyric dehydrogenase of muitochondria.
    J Biol Chem. 1960 Aug;235:2450-5 PMID: 14415394
  88. Drug oxidations dependent on cytochrome P-450 in isolated hepatocytes. The role of the tricarboxylates and the aminotransferases in NADPH supply.
    Eur J Biochem. 1977 Jul 15;77(2):401-8 PMID: 19252
  89. Influence of hormones on liver. I. Effects of steroids and thyroxine on pyridine nucleotide-linked dehydrogenases.
    J Exp Med. 1959 Dec 1;110:899-919 PMID: 14403829
  90. Stoppage of glycogenesis and "over-shoot" of induction of lipogenesis and its related enzyme activities in the liver of fasted-refed rats.
    J Nutr. 1976 Jan;106(1):136-41 PMID: 173817
  91. Interrelation of aerobic glycolysis and lipogenesis in isolated perfused liver of well-fed rats.
    Biochim Biophys Acta. 1978 Feb 13;539(1):62-80 PMID: 623794
  92. A quantitative study of the validity of the histochemical demonstration for pyridine nucleotide-linked dehydrogenases.
    Histochemie. 1965;5(5):430-6 PMID: 5887421
  93. Interaction of mixed-function oxidation with biosynthetic processes. 1. Inhibition of gluconeogenesis by aminopyrine in perfused rat liver.
    Eur J Biochem. 1973 Sep 21;38(1):64-72 PMID: 4149430
  94. Decreased cAMP responsiveness to glucagon in livers from ethynyl estradiol treated rats.
    Biochem Biophys Res Commun. 1979 Jan 30;86(2):454-9 PMID: 218573
  95. The citrate enzymes: their structures, mechanisms, and biological functions.
    Curr Top Cell Regul. 1972;5:229-83 PMID: 4587829
  96. Cytochrome P-450 distribution in rat liver and the effect of sodium phenobarbitone administration.
    Chem Biol Interact. 1978 Mar;20(3):299-310 PMID: 207450
  97. NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE-SPECIFIC DEHYDROGENASES IN RELATION TO LIPOGENESIS.
    Biochim Biophys Acta. 1964 Jun 15;84:239-50 PMID: 14194230
  98. Physiological roles of ketone bodies as substrates and signals in mammalian tissues.
    Physiol Rev. 1980 Jan;60(1):143-87 PMID: 6986618
  99. Demonstration of a D-glucose transport system in the biliary tree of the rat by use of the segmented retrograde intrabiliary injection technique.
    Biochem Pharmacol. 1980 Feb;29(2):213-9 PMID: 6767480
  100. Effect of diet on activity of enzymes involved in fatty acid and cholesterol synthesis.
    Adv Lipid Res. 1974;12(0):97-146 PMID: 4153652
  101. Multiple oestrogen-binding macromolecules in rat liver cytosol [proceedings].
    Arch Int Physiol Biochim. 1979 May;87(2):406-8 PMID: 92955
  102. Long-term effects of starvation-refeeding in the rat.
    Nutr Metab. 1975;19(1-2):45-54 PMID: 1226270
  103. Effects of hormones on hepatic glucose 6-phosphate dehydrogenase of rat.
    J Histochem Cytochem. 1967 Sep;15(9):530-4 PMID: 4228333
  104. [Glycolysis in specialized liver parenchymal cells? (author's transl)].
    Eur J Cell Biol. 1980 Apr;21(1):72-8 PMID: 7379799
  105. NADP-dependent dehydrogenases in rat liver parenchyma. I. Methodological studies on the qualitative histochemistry of G6PDH, 6PGDH, malic enzyme and ICDH.
    Histochemistry. 1978 Jul 12;56(3-4):283-98 PMID: 29020
  106. The microcirculatory acinar concept of normal and pathological hepatic structure.
    Beitr Pathol. 1976 May;157(3):215-43 PMID: 1275864
  107. Effects of antecedent food intake pattern on hepatic lipogenesis.
    Am J Physiol. 1958 Apr;193(1):55-64 PMID: 13520982
  108. Synthesis and degradation of the lipogenic enzymes of rat liver.
    Adv Enzyme Regul. 1972;10:187-204 PMID: 4653823
  109. Interaction of mixed-function oxidation with biosynthetic processes. 2. Inhibition of lipogenesis by aminopyrine in perfused rat liver.
    Eur J Biochem. 1973 Sep 21;38(1):73-8 PMID: 4774126
  110. Inhibition of rat liver glucose-6-phosphate dehydrogenase synthesis by glucagon.
    J Biol Chem. 1975 May 25;250(10):3960-5 PMID: 805134
  111. Comparison of metabolism of free fatty acid by isolated perfused livers from male and female rats.
    J Lipid Res. 1976 Nov;17(6):605-15 PMID: 1032892
  112. On the ethionine-induced fatty liver in male and female rats.
    Lab Invest. 1967 Sep;17(3):299-307 PMID: 6051012
  113. Isolation and purification of a regulating cofactor of the pentose-phosphate pathway.
    Biochem Biophys Res Commun. 1979 Jul 12;89(1):148-54 PMID: 475804
  114. The cytoplasmic distribution of isocitric dehydrogenases.
    Exp Cell Res. 1956 Aug;11(2):483-6 PMID: 13375670
  115. Functional heterogeneity of rat liver parenchyma and of isolated hepatocytes.
    FEBS Lett. 1975 Sep 1;57(1):83-8 PMID: 170133
  116. The distribution of glutathione in the rat liver lobule.
    Biochem J. 1979 Jul 15;182(1):103-8 PMID: 496899
  117. A process requiring mitochondrial NADPH: urea formation from ammonia.
    FEBS Lett. 1975 Jun 15;54(2):274-8 PMID: 236928
  118. Extent and patterns of adaptation of enzyme activities in livers of normal rats fed diets high in glucose and fructose.
    J Biol Chem. 1960 Mar;235:554-7 PMID: 13823292
  119. Physiological aspects of the regulation of ketogenesis.
    Biochem Soc Symp. 1978;(43):137-61 PMID: 571280
  120. Mechanism of oestrogen and progesterone effects on lipid and carbohydrate metabolism: alteration in the insulin: glucagon molar ratio and hepatic enzyme activity.
    Eur J Clin Invest. 1977 Jun;7(3):181-7 PMID: 19260
  121. Effects of ethynyl estradiol on serum lipoprotein lipids in male and female rats.
    Biochim Biophys Acta. 1978 Sep 28;530(3):394-401 PMID: 212109
  122. Heterogeneous distribution of glucose-6-phosphatase in microdissected periportal and perivenous rat liver tissue.
    FEBS Lett. 1977 Apr 15;76(2):226-30 PMID: 193728
  123. [FATTY LIVER].
    Munch Med Wochenschr. 1965 Jun 4;107:1141-7 PMID: 14307665
  124. Proportions of mitochondrial enzymes and pyridine nucleotides.
    Biochem Biophys Res Commun. 1962 Jun 4;7:430-2 PMID: 14457017
  125. Binding of specific ATP citrate lyase and fatty acid synthetase antibodies to heavy populations of rat liver polysomes.
    Eur J Biochem. 1979 Aug 15;99(1):209-16 PMID: 114394
  126. MALIC ENZYME AND LIPOGENESIS.
    Proc Natl Acad Sci U S A. 1964 Nov;52:1255-63 PMID: 14231450
  127. Cell heterogeneity within the hepatic lobule: quantitative histochemistry.
    J Histochem Cytochem. 1959 Jul;7(4):237-9 PMID: 13664970
  128. Effects of 2,4-dihydroxybutyrate on lipogenesis in rat hepatocytes.
    J Biol Chem. 1979 Dec 10;254(23):11969-72 PMID: 500686
  129. Mitochondrial and cytosolic NADPH systems and isocitrate dehydrogenase indicator metabolites during ureogensis from ammonia in isolated rat hepatocytes.
    Eur J Biochem. 1977 Jan;72(2):301-7 PMID: 13998
  130. Fatty acid and 3- -hydroxysterol synthesis in the perfused rat liver. Including measurements on the production of lactate, pyruvate, -hydroxy-butyrate, and acetoacetate by the fed liver.
    J Biol Chem. 1973 Apr 25;248(8):2656-69 PMID: 4697388
  131. Recent developments in ketone-body metabolism.
    Biochem Soc Trans. 1979 Dec;7(6):1313-21 PMID: 394998
  132. Cell heterogeneity within the hepatic lobule of the rat: staining reactions.
    J Histochem Cytochem. 1959 Jul;7(4):240-4 PMID: 13664971
  133. Zonal changes in the rat liver following an acute dose of phenobarbitone: an ultrastructural, morphometric and biochemical correlation.
    Chem Biol Interact. 1981 Feb;34(1):31-8 PMID: 7460076
  134. Effect of dietary change on the rates of synthesis and degradation of rat liver fatty acid synthetase.
    Arch Biochem Biophys. 1972 Oct;152(2):619-30 PMID: 4628998
  135. The diagnostic significance of liver cell inhomogeneity: serum enzymes in patients with central liver necrosis and the distribution of glutamate dehydrogenase in normal human liver.
    Z Klin Chem Klin Biochem. 1975 Jul;13(7):311-8 PMID: 1189532
  136. Changes in distribution of lipid, glucose-6-phosphate dehydrogenase and malate enzyme within the liver lobule of the rat during adaptive hyperlipogenesis.
    Anat Rec. 1973 Feb;175(2):231-41 PMID: 4685558
  137. Translation of rat liver fatty acid synthetase mRNA in a cell-free system derived from wheat germ.
    Proc Natl Acad Sci U S A. 1978 Feb;75(2):730-4 PMID: 273236
  138. Estrogen receptor in rat liver: translocation to the nucleus in isolated parenchymal cells.
    Endocrinology. 1979 Sep;105(3):627-35 PMID: 467323
  139. METABOLIC AND HORMONAL CONTROL OF PHOSPHOENOLPYRUVATE CARBOXYKINASE AND MALIC ENZYME IN RAT LIVER.
    J Biol Chem. 1963 Oct;238:3188-92 PMID: 14085360
  140. The use of a non-ionic detergent (Triton WR 1339) to determine rates of triglyceride entry into the circulation of the rat under different physiological conditions.
    J Physiol. 1967 May;190(2):321-32 PMID: 6049002
  141. Lipogenesis in rat hepatocytes.
    J Biol Chem. 1974 Apr 10;249(7):2028-36 PMID: 4362059
  142. Dietary induction of hepatic malic enzyme activity: differentiation of the induction process.
    Life Sci. 1974 Apr 16;14(8):1563-75 PMID: 4829546
  143. Alterations in nicotinamide and adenine nucleotide systems during mixed-function oxidation of p-nitroanisole in perfused livers from normal and phenobarbital-treated rats.
    Biochem J. 1977 Sep 15;166(3):583-92 PMID: 23104
  144. Interaction of mixed function oxidase with its substrates and associated redox transitions of cytochrome P-450 and pyridine nucleotides in perfused rat liver.
    Eur J Biochem. 1970 Sep;15(3):531-40 PMID: 4393943
  145. Changes in distribution of enzymes within the liver lobule during adaptive increases.
    J Histochem Cytochem. 1972 Feb;20(2):107-11 PMID: 4400699
  146. [The fructose induced "glycogenosis". II. Histochemical studies of glycogen metabolism in rat liver after fructose overload and similar diets (author's transl)].
    Beitr Pathol. 1976 Feb;157(1):56-75 PMID: 178297
  147. FATTY ACID SYNTHESIS DURING FAT-FREE REFEEDING OF STARVED RATS.
    J Lipid Res. 1965 Jan;6:63-74 PMID: 14280474
  148. Histochemical demonstration of enzymes related to NADPH-dependent hydroxylating systems in rat liver after phenobarbital treatment.
    Histochemie. 1969;20(1):68-77 PMID: 4391104
  149. Effect of phagocytosis on the carbohydrate metabolism of polymorphonuclear leucocytes.
    Biochim Biophys Acta. 1966 May 26;121(1):110-9 PMID: 4381015
  150. Some aspects of the gonadal regulation of cholesterol metabolism.
    Am J Physiol. 1958 Apr;193(1):47-51 PMID: 13520980
  151. Rate-limiting function of 3-hydroxy-3-methylglutaryl-coenzyme A synthase in ketogenesis.
    Biochem Med. 1979 Dec;22(3):365-74 PMID: 93966
  152. Regulation of rat liver acetyl-CoA carboxylase. Stimulation of phosphorylation and subsequent inactivation of liver acetyl-CoA carboxylase by cyclic 3':5'-monophosphate and effect on the structure of the enzyme.
    J Biol Chem. 1978 Nov 25;253(22):8149-56 PMID: 30774
  153. Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver.
    J Biol Chem. 1969 Nov 25;244(22):6254-62 PMID: 4981792
  154. Chemomorphology of liver parenchyma. Qualitative histochemical distribution patterns and quantitative sinusoidal profiles of G6Pase, G6PDH and malic enzyme activity and of glycogen content.
    Prog Histochem Cytochem. 1981;14(3):1-92 PMID: 6283597
  155. Hormonal regulation of glucokinase in primary cultures of rat hepatocytes.
    Eur J Biochem. 1979 Jul;98(1):77-82 PMID: 467450
  156. Control mechanisms in the synthesis of saturated fatty acids.
    Annu Rev Biochem. 1977;46:263-98 PMID: 20038
  157. Interactions of tissue glucose-6-phosphate dehydrogenase (G6PD) activity with age and sexual development in the rat.
    Endokrinologie. 1969;54(1):85-97 PMID: 4391115
  158. The effects of starvation and refeeding on carbohydrate and lipid metabolism in vivo and in the perfused rat liver. The relationship between fatty acid oxidation and esterification in the regulation of ketogenesis.
    J Biol Chem. 1973 Jan 10;248(1):270-8 PMID: 4692833
  159. Liver cell heterogeneity. The distribution of pyruvate kinase and phosphoenolpyruvate carboxykinase (GTP) in the liver lobule of fed and starved rats.
    Hoppe Seylers Z Physiol Chem. 1976 Dec;357(12):1793-800 PMID: 1017801
  160. Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues.
    Biochem J. 1971 Jan;121(1):41-7 PMID: 5165621
  161. Quantitative determination of G6Pase activity in histochemically defined zones of the liver acinus.
    Histochemistry. 1978 Dec 13;58(4):281-8 PMID: 216655
  162. Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine 3':5' cyclic monophosphate.
    Proc Natl Acad Sci U S A. 1972 Dec;69(12):3516-9 PMID: 4345502
  163. METABOLIC CONTROL OF ENZYMES INVOLVED IN LIPOGENESIS AND GLUCONEOGENESIS.
    Biochemistry. 1964 Nov;3:1687-92 PMID: 14235331
  164. Effect of streptozotocin diabetes and insulin administration on some liver enzyme activities in the post-weaning rat.
    Enzyme. 1978;23(6):382-7 PMID: 729537
  165. Induction of glucokinase by insulin under the permissive action of dexamethasone in primary rat hepatocyte cultures.
    Biochem Biophys Res Commun. 1979 May 14;88(1):23-9 PMID: 454445
  166. The histochemical localization of lactic dehydrogenase isoenzymes in the rat nephron by means of an improved polyvinyl alcohol method.
    Histochemie. 1969;20(3):250-65 PMID: 4190307
Article Info
Journal
Histochemistry
Abbr.
Histochemistry
ISSN
0301-5564
DOI
10.1007/BF00493277
Published
1981-00-00
Pages
579-615
Language
English
Region
Germany
NLM ID
0411300
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00493277
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2