Increase in in vivo (3H) spiperone binding in the rat hippocampal formation and striatum after repeated treatment with haloperidol.

Experientia ·Vol. 37 ·No. 9 ·1981-00-00 ·Pages 1008-9

Bischoff S

Abstract

An increase in in vivo (3H) spiperone binding was observed in rat hippocampal formation and striatum after repeated treatment with haloperidol. This suggests that in hippocampus as well as in striatum prolonged blockade of dopaminergic transmission by a neuroleptic agent results in the development of a supersensitivity of the dopamine receptors.

MeSH Terms

Animals Butyrophenones/metabolism Corpus Striatum/metabolism Haloperidol/pharmacology Hippocampus/metabolism Kinetics Male Rats Receptors, Dopamine/drug effects Spiperone/metabolism

Chemicals

Butyrophenones Receptors, Dopamine Spiperone Haloperidol

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Bischoff S

References (10)

10 references, click to expand

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Brain Res. 1979 Dec 7;178(1):17-40 PMID: 91413
Differential changes in DOPAC levels in the hippocampal formation, septum and striatum of the rat induced by acute and repeated neuroleptic treatment.
Eur J Pharmacol. 1981 May 22;71(4):499-503 PMID: 6113973
Apomorphine and glycoprotein synthesis in rat hippocampus.
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The membrane potential of cat hippocampal neurons recorded in vivo displays four different reaction-mechanisms to iontophoretically applied transmitter agonists.
Brain Res. 1981 May 18;212(2):331-43 PMID: 6112049
Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain.
Science. 1977 Apr 15;196(4287):326-8 PMID: 847477
Biochemical evidence for a transmitter role of dopamine in the rat hippocampus.
Brain Res. 1979 Apr 6;165(1):161-5 PMID: 218689
Dopamine metabolism, spiperone binding and adenylate cyclase activity in the adult rat hippocampus after ingrowth of dopaminergic neurones from embryonic implants.
Brain Res. 1979 Dec 21;179(1):77-84 PMID: 509234
Increased in vivo binding of 3H-pimozide in mouse striatum following repeated administration of haloperidol.
Life Sci. 1978 Oct 30;23(17-18):1785-9 PMID: 569235
In vivo [3H]spiperone binding to the rat hippocampal formation: involvement of dopamine receptors.
Eur J Pharmacol. 1980 Dec 5;68(3):305-15 PMID: 7202494
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Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01971808

Published

1981-00-00

Pages

1008-9

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01971808

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Increase in in vivo (3H) spiperone binding in the rat hippocampal formation and striatum after repeated treatment with haloperidol.

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