Frequency of naturally occurring antibody to influenza virus antigenic variants selected in vitro with monoclonal antibody.

The Journal of hygiene ·Vol. 87 ·No. 2 ·1981-10-00 ·Pages 185-90

Natali A, Oxford JS, Schild GC

Abstract

Antigenic variants of A/Texas/77 (H3N2) virus were selected in vitro using monoclonal antibody to virus haemagglutinin (HA). The antigenic variants and parental A/Texas/77 viruses were used to to evaluate the frequency of anti-HA antibodies in the sera of children and adults using single-radial-haemolysis (SRH) tests. Twenty to 41% of selected sera from adults, which contained antibody to the parental A/Texas/77 virus, failed to react with the different antigenic mutant viruses. A higher proportion of sera from children (37-58%) failed to react with the antigenic variants. Certain human sera and particularly those of children would appear to possess a more limited antibody repertoire to influenza HA, potentially allowing new antigenic variants to escape neutralization and spread in the community.

MeSH Terms

Adolescent Adult Aged Antibodies, Monoclonal/analysis Antibodies, Viral/analysis Antigens, Viral/genetics Child, Preschool Genetic Variation Humans Infant Middle Aged Mutation Orthomyxoviridae/genetics,immunology

Chemicals

Antibodies, Monoclonal Antibodies, Viral Antigens, Viral

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Natali A

Oxford J S

Schild G C

References (10)

10 references, click to expand

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Article Info

Journal

The Journal of hygiene

Abbr.

J Hyg (Lond)

ISSN

0022-1724

DOI

10.1017/s0022172400069394

Published

1981-10-00

Pages

185-90

Language

English

Region

England

NLM ID

0375374

PMCID

PMC2134050

Subset

External Links

PubMed source DOI: 10.1017/s0022172400069394 PMC Full Text View journal details

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Frequency of naturally occurring antibody to influenza virus antigenic variants selected in vitro with monoclonal antibody.

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