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PMID: 7287080 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

"Natural" antibodies to chicken MHC antigens are present in mice, rats, humans, alligators and allogeneic chickens.

Immunogenetics ·Vol. 11 ·No. 3 ·1980-00-00 ·Pages 293-302

Longenecker BM, Mosmann TR

Abstract

In the absence of any deliberate immunization, mice, rats, humans and alligators all have detectable titers of antibody against chicken red blood cells (CRBC's). Remarkably, this antibody is directed predominantly against private or public determinants of MHC proteins on the CRBC's, and little or no antibody is directed against species-specific determinants on MHC or other proteins, including other polymorphic blood group antigens. In chickens, "natural" antibody can be detected against CRBC's from all chickens differing at the MHC locus, but "natural" antibodies against other polymorphic antigens are not detected. Using a rosette-forming cell (RFC) assay, we have also shown that a large percentage of mouse spleen cells will rosette with chicken erythrocytes, and that the majority of these RFC's also recognize polymorphic antigens.

MeSH Terms
Alligators and Crocodiles/immunology Animals Antibodies Blood Group Antigens/immunology Chickens/immunology Erythrocytes/immunology Humans Major Histocompatibility Complex Mice Muridae/immunology Rats Rosette Formation Species Specificity
Chemicals
Antibodies Blood Group Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Longenecker B M
Mosmann T R
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19 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF01567795
Published
1980-00-00
Pages
293-302
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01567795 View journal details
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