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PMID: 7286992 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Conserved repeated DNA sequences in vertebrate sex chromosomes.

Human genetics ·Vol. 58 ·No. 1 ·1981-00-00 ·Pages 46-53

Jones KW, Singh L

Abstract

Satellite DNA isolated from female Elapid snakes contains nucleotide sequences which are quantitatively derived from the W sex-determining chromosome. Certain of these sequences are highly conserved in vertebrates, including mammals, where they are arranged in a sex-specific pattern in Southern blots. Sex reversed mice (Sxr) show a DNA arrangement of these sequences in conformity with their phenotypic sex, suggesting that this DNA is closely connected with the determination of sex. In situ hybridization of the snake sequences with mouse chromosomes reveals a concentration of related DNA at the proximal tip of the mouse Y chromosome. This possible nature and significance of these observations is discussed.

MeSH Terms
Animals Birds/genetics DNA, Satellite/genetics Female Heterochromatin Humans Male Mice Mice, Mutant Strains/genetics Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid Sex Chromosomes Sex Determination Analysis Sex Differentiation Snakes/genetics Transcription, Genetic Y Chromosome
Chemicals
DNA, Satellite Heterochromatin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jones K W
Singh L
References (13)
13 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00284148
Published
1981-00-00
Pages
46-53
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00284148 View journal details
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