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PMID: 7277208 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Kinetics of drug displacement interactions.

Journal of pharmacokinetics and biopharmaceutics ·Vol. 9 ·No. 2 ·1981-04-00 ·Pages 181-90

Aarons LJ, Rowland M

Abstract

A simple model simulating the kinetics of drugs displacement kinetics is investigated. It is demonstrated that for highly bound, lowly cleared drugs, displacement interactions are transitory. Consequently, the kinetics of the interaction have to be considered as well as the in vitro interaction. It is possible to have a significant in vitro displacement interaction with no in vivo counterpart. Methods of moderating drug displacement by adjusting the rate and the timing of administration of the displacing agent are discussed.

MeSH Terms

Binding, Competitive Drug Interactions Half-Life Humans Kinetics Models, Biological Protein Binding

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Aarons L J

Rowland M

References (8)

8 references, click to expand

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Article Info

Journal

Journal of pharmacokinetics and biopharmaceutics

Abbr.

J Pharmacokinet Biopharm

ISSN

0090-466X

DOI

10.1007/BF01068081

Published

1981-04-00

Pages

181-90

Language

English

Region

United States

NLM ID

0357115

Subset

External Links

PubMed source DOI: 10.1007/BF01068081

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Kinetics of drug displacement interactions.

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